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CaV3.2 Antibody (PA5-106771) in ICC/IF
Immunofluorescent analysis of CaV3.2 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and CaV3.2 polyclonal antibody (Product # PA5-106771) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-106771
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CACNA1H(Accession O95180), corresponding to amino acid residues E570-G620.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2854439
产品详细信息
Antibody detects endogenous levels of total CACNA1H.
靶标信息
This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: A1H-b; calcium channel alpha13.2 subunit; calcium channel, voltage-dependent, T type, alpha 1H subunit; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; FLJ90484; Low-voltage-activated calcium channel alpha1 3.2 subunit; low-voltage-activated calcium channel alpha13.2 subunit; T-type Cav3.2; voltage dependent t-type calcium channel alpha-1H subunit; Voltage-dependent T-type calcium channel subunit alpha-1H; voltage-gated calcium channel alpha subunit Cav3.2; voltage-gated calcium channel alpha subunit CavT.2; Voltage-gated calcium channel subunit alpha Cav3.2
基因别名: alpha13.2; CACNA1H; CACNA1HB; Cav3.2; ECA6; EIG6; MNCb-1209
UniProt ID: (Human) O95180, (Rat) Q9EQ60
Entrez Gene ID: (Human) 8912, (Rat) 114862, (Mouse) 58226
transport
muscle contraction
muscle organ development
myoblast fusion
regulation of heart contraction
aldosterone biosynthetic process
cellular response to hormone stimulus
cortisol biosynthetic process
regulation of ion transmembrane transport
cellular response to potassium ion
regulation of membrane potential
calcium ion import
calcium ion transmembrane transport
membrane depolarization during action potential
positive regulation of acrosome reaction
calcium ion transport
sensory perception of pain
positive regulation of calcium ion-dependent exocytosis
ion transport
ion transmembrane transport
transmembrane transport
