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Antibody is stable for 24 months.
Positive Control: Human thyroid. Cellular Localization: Cytoplasm. Secreted
Specificity Comments: Calcitonin is a 32 amino acid polypeptide hormone that preserves skeletal integrity and reduces blood calcium levels by decreasing osteoclast activity in bones, calcium and phosphate reabsorption by kidney tubules and calcium absorption by the intestines. The secretion of Calcitonin from the thyroid is regulated in part by estrogen, which increases Calcitonin mRNA levels. The Calcitonin gene, CALCA, undergoes tissue-specific RNA alternative splicing, resulting in the production of different mRNA transcripts. One transcript encodes procalcitonin as well as both calcium-lowering processed active polypeptides, Calcitonin and katacalcin. An alternative transcript of CALCA encodes the precursor for the neuropeptide referred to as Calcitonin generelated peptide 1, also designated CGRP1 or -CGRP. Mature CGRP1 and CGRP2 share significant sequence identity at the protein level differing by only 1-3 amino acid residues, depending on the species.
Calcitonin is a 32 amino acid peptide which can be demonstrated in C cells of the normal and hyperplastic thyroid. Staining for calcitonin may be used for the identification of a spectrum of C cell proliferative abnormalities ranging from C cell hyperplasia to invasive tumors. Staining for calcitonin in medullary carcinoma of the thyroid produces a fine granular pattern in the cytoplasm. Amyloid deposits within the tumor may also exhibit varying degrees of calcitonin activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Alpha CGRP; Alpha type CGRP; Alpha-type CGRP; Calcitonin; calcitonin 1; calcitonin gene related peptide 1; Calcitonin gene-related peptide 1; Calcitonin gene-related peptide I; calcitonin-related polypeptide alpha; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; katacalcin; katacalcin (KC)
基因别名: CALC1; CALCA; CGRP; CGRP-I; CGRP1; CT; KC; PCT
UniProt ID: (Human) P06881
Entrez Gene ID: (Human) 796
分子生物学功能: peptide hormone