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Calmodulin 3 Antibody (PA5-29980) in WB
Western Blot using Calmodulin 3 Polyclonal Antibody (Product # PA5-29980). Various tissue extracts (50 µg) were separated by 15% SDS-PAGE, and the membrane was blotted with Calmodulin 3 Polyclonal Antibody (Product # PA5-29980) diluted at 1:1,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
产品信息
PA5-29980
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 1 and 99 of Human Calmodulin 3
偶联物
形式
Liquid
浓度
0.48 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2547454
产品详细信息
Recommended positive controls: Mouse brain.
Predicted reactivity: Mouse (100%), Rat (100%), Pig (100%), Bovine (100%), Guinea pig (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP7 (Calcium-binding protein 7), contains two EF-hand domains for calcium binding and shares 70% homology with CaBP8 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. CaBP7 and 8 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: calmodulin; calmodulin 3 (phosphorylase kinase, delta); Calmodulin III; Calmodulin-1; Calmodulin-2; Calmodulin-3; caM; epididymis secretory protein Li 72; phosphorylase kinase subunit delta; prepro-calmodulin 3
基因别名: CALM; CALM1; CALM2; CALM3; CALML2; CAM; CAM1; CAM2; CAM3; CaMA; CAMB; CAMC; CaMI; CaMII; CAMIII; HEL-S-72; PHKD; PHKD3; R75142; RNCAMIII
UniProt ID: (Human) P0DP24, (Rat) P0DP29, (Mouse) P0DP27
Entrez Gene ID: (Human) 808, (Rat) 24244, (Mouse) 12315
Ras guanyl-nucleotide exchange factor activity
calcium ion binding
protein binding
adenylate cyclase binding
inositol-1,4,5-trisphosphate 3-kinase activity
ligand-gated ion channel activity
protein kinase binding
protein domain specific binding
nitric-oxide synthase regulator activity
titin binding
type 3 metabotropic glutamate receptor binding
thioesterase binding
N-terminal myristoylation domain binding
phospholipase binding
protein serine/threonine kinase activator activity
phosphatidylinositol 3-kinase binding
ion channel binding
calcium-dependent protein binding
nitric-oxide synthase binding
protein phosphatase activator activity
enzyme regulator activity
protein N-terminus binding
calmodulin-related
G2/M transition of mitotic cell cycle
MAPK cascade
response to amphetamine
regulation of heart rate
platelet degranulation
detection of calcium ion
glycogen catabolic process
muscle contraction
G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
Wnt signaling pathway, calcium modulating pathway
positive regulation of peptidyl-threonine phosphorylation
negative regulation of peptidyl-threonine phosphorylation
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
substantia nigra development
regulation of rhodopsin mediated signaling pathway
positive regulation of cyclic nucleotide metabolic process
positive regulation of protein autophosphorylation
regulation of cytokinesis
positive regulation of phosphoprotein phosphatase activity
ion transmembrane transport
positive regulation of protein dephosphorylation
Fc-epsilon receptor signaling pathway
positive regulation of DNA binding
positive regulation of GTPase activity
inositol phosphate metabolic process
regulation of nitric-oxide synthase activity
positive regulation of nitric-oxide synthase activity
positive regulation of cyclic-nucleotide phosphodiesterase activity
response to corticosterone
response to calcium ion
regulation of cardiac muscle contraction
negative regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of protein serine/threonine kinase activity
regulation of high voltage-gated calcium channel activity
regulation of cell communication by electrical coupling involved in cardiac conduction
calcium-mediated signaling
regulation of ryanodine-sensitive calcium-release channel activity
regulation of store-operated calcium channel activity
regulation of catalytic activity
