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产品信息
PA5-76774
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length Human Calpain 3.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2720501
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
Calpain, an intracellular calcium-dependent protease that cleaves cytoskeletal and submembranous proteins, plays a role in cytoskeletal reorganization and muscle protein degradation. Calpain is a heterodimer composed of a small regulatory subunit and one of three large catalytic subunits, designated calpain 1, calpain 2 and calpain 3. Calpain 3 (calpain p94) is a muscle-preferred calcium activated neutral protease that localizes to the nucleus. Mutations involving the calpain 3 gene are associated with limb-girdle muscle dystrophy type 2A, a form of autosomal recessive and progressive neuromuscular diso4. Calpastatin regulates calpain by inhibiting both the proteolytic activity of calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calcium-activated neutral proteinase 3; calpain 3, (p94); Calpain L3; Calpain p94; calpain p94, large [catalytic] subunit; calpain, large polypeptide L3; Calpain-3; CANP 3; CAPN 3; LGMD 2A; MGC10767; MGC11121; MGC14344; MGC4403; Muscle-specific calcium-activated neutral protease 3; muscle-specific calcium-activated neutral protease 3 large subunit; nCL-1; New calpain 1; skeletal muscle specific calpain p94
基因别名: AI323605; CANP3; CANPL3; Capa-3; Capa3; CAPN3; LGMD2; LGMD2A; Lp82; Lp84; Lp85; nCL-1; NCL1; p94
UniProt ID: (Human) P20807, (Mouse) Q64691, (Rat) P16259
Entrez Gene ID: (Human) 825, (Mouse) 12335, (Rat) 29155
catalytic activity
calcium-dependent cysteine-type endopeptidase activity
signal transducer activity
calcium ion binding
protein binding
peptidase activity
cysteine-type peptidase activity
structural constituent of muscle
sodium ion binding
titin binding
protein complex scaffold
ligase regulator activity
receptor binding
hydrolase activity
enzyme binding
metal ion binding
cysteine protease
protein complex assembly
proteolysis
apoptotic process
signal transduction
muscle organ development
positive regulation of satellite cell activation involved in skeletal muscle regeneration
response to muscle activity
myofibril assembly
negative regulation of protein sumoylation
negative regulation of apoptotic process
regulation of I-kappaB kinase/NF-kappaB signaling
sarcomere organization
regulation of myoblast differentiation
positive regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
muscle cell cellular homeostasis
regulation of catalytic activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of release of sequestered calcium ion into cytosol
response to calcium ion
muscle structure development
G1 to G0 transition involved in cell differentiation
cellular response to calcium ion
cellular response to salt stress
protein localization to membrane
self proteolysis
negative regulation of skeletal muscle cell differentiation
autolysis
sodium-dependent self proteolysis
response to drug
