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Invitrogen
Cannabinoid Receptor 1 Polyclonal Antibody
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产品信息
PA1-745
应用
建议稀释比
已发表文章
产品规格
种属反应
Amphibian,
Chicken,
Fish,
Human,
Mouse,
Non-human primate,
Rat
已发表种属
Chicken,
Cynomolgus monkey,
Ferret,
Human,
Mouse,
Rabbit,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A fusion protein containing the first 77 amino acid residues from rat CB1.
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 1mg/mL BSA, 50% glycerol
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-745 detects cannabinoid receptor 1 (CB1) from human, rat, monkey, mouse, chicken, salamander and goldfish tissues. This antibody detects a few non-specific bands in NIH-3T3 and HT-29 cell lysates.
PA1-745 has been successfully used in Western blot, FACS, immunohistochemistry, and immunocytochemistry procedures. By Western blot, this antibody detects a ~60 kDa protein representing CB1 and less intense bands of ~23 kDa, ~72 kDa, and ~180 kDa from rat brain homogenate. Immunocytochemical staining of CB1 in living or fixed cultured hippocampal neurons with PA1-745 results in intense, punctate staining along processes, with little staining over cell bodies.
PA1-745 antigen is a fusion protein containing the first 77 amino acid residues of the rat CB1 receptor.
靶标信息
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Brain-type cannabinoid receptor; CANN6; Cannabinoid receptor 1; cannabinoid receptor 1 (brain); CB-R; CB1; CB1 cannabinoid receptor; CB1 receptor; central cannabinoid receptor; HGNC:2159; OTTHUMP00000016839; RP1-23D17.1; seven transmembrane domains; G-protein-coupled receptor; striatal cannabinoid receptor type 1 protein
基因别名: CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR; CNR1; Skr6; SKR6R
UniProt ID: (Human) Q5UB37, (Mouse) P47746, (Rat) P20272
Entrez Gene ID: (Human) 1268, (Chicken) 428633, (Mouse) 12801, (Rat) 25248
positive regulation of acute inflammatory response to antigenic stimulus
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
spermatogenesis
axonal fasciculation
aging
response to nutrient
memory
positive regulation of neuron projection development
sensory perception of pain
positive regulation of fever generation
negative regulation of fatty acid beta-oxidation
regulation of synaptic transmission, GABAergic
response to lipopolysaccharide
negative regulation of mast cell activation
negative regulation of dopamine secretion
response to nicotine
cannabinoid signaling pathway
response to cocaine
glucose homeostasis
positive regulation of apoptotic process
negative regulation of ion transport
response to morphine
response to ethanol
negative regulation of action potential
negative regulation of blood pressure
positive regulation of blood pressure
regulation of insulin secretion
negative regulation of nitric-oxide synthase activity
regulation of synaptic transmission, glutamatergic
maternal process involved in female pregnancy
regulation of feeding behavior
regulation of penile erection
signal transduction
G-protein coupled receptor signaling pathway
learning or memory
regulation of lipid metabolic process
