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Invitrogen
Caspase 1 p10/p12 Recombinant Rabbit Monoclonal Antibody (JE56-35)
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Caspase 1 p10/p12 Antibody (MA5-56516) in ICC/IF
Immunocytochemistry analysis of Caspase 1 p10/p12 with RAW264.7 cells. Cells were fixed in 4% paraformaldehyde (20 min, room temp), permeabilized with 0.1% Triton X-100 in PBS (5 min, room temp), then blocked with 1% BSA in 10% negative goat serum (1 hr, room temp). Next they were incubated with Caspase 1 p10/p12 Recombinant Monoclonal Antibody (Product # MA5-56516)at a dilution of 1:100 in 1% BSA in PBST o... View More
产品信息
MA5-56516
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JE56-35
抗原
Recombinant protein within human caspase-1 aa 255-404/404.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Caspase-1, also known as Interleukin-1β-converting enzyme (ICE), is an inflammatory caspase responsible for processing pro-inflammatory cytokines like IL-1 beta and IL-18, and inducing pyroptosis, a form of programmed cell death. The active form of caspase-1 is a heterotetramer consisting of two p20 and two p10 subunits. The p10 subunit arises from the cleavage of the pro-caspase-1 precursor, which is essential for the enzyme's activation and function. The p12 subunit is a fragment derived from the cleavage of the proenzyme, which is involved in enzyme regulation. Upon activation, caspase-1 cleaves its substrates, leading to the initiation of inflammatory responses and pyroptotic pathways. The regulation of these subunits and their precise activities are crucial for maintaining immune homeostasis and responding to infections and tissue damage.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CASP-1; CASP1 nirs variant 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); Caspase-1; ICE; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL-1BC; IL1B-convertase; interleukin 1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin 1beta converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45
基因别名: CASP1; ICE; IL1BC; IL1BCE; P45
UniProt ID: (Human) P29466, (Mouse) P29452
Entrez Gene ID: (Human) 834, (Mouse) 12362, (Rat) 25166
endopeptidase activity
cysteine-type endopeptidase activity
protein binding
cysteine-type endopeptidase activator activity involved in apoptotic process
cysteine-type endopeptidase activity involved in apoptotic process
peptidase activity
cysteine-type peptidase activity
hydrolase activity
scaffold protein binding
protease
response to hypoxia
proteolysis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
regulation of autophagy
protein processing
response to lipopolysaccharide
interleukin-1 beta production
response to ATP
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
regulation of inflammatory response
mitochondrial depolarization
membrane hyperpolarization
pyroptosis
cellular response to mechanical stimulus
cellular response to organic substance
programmed necrotic cell death
toxin transport
microglial cell activation
myoblast fusion
memory
response to bacterium
response to organic cyclic compound
response to drug
positive regulation of apoptotic process
positive regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of cytokine secretion
midgut development
response to toxic substance
lung development
execution phase of apoptosis
