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Catenin alpha-1 Antibody (PA5-79091) in Flow
Flow Cytometry of Catenin alpha-1 in HeLa cells (blue line), isotype control rabbit IgG (green line) and unlabeled (red line). Samples were blocked with 10% goat serum and then incubated with Catenin alpha-1 Polyclonal Antibody, DyLight™ 488 (Product # PA5-79091) at a dilution of 1 μg (per 1x10^6 cells) for 30 min at 20°C.
产品信息
PA5-79091
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human CTNNA1 recombinant protein (Position: D143-D292).
偶联物
激发/发射光谱
492/519 nm
查看光谱
形式
Liquid
浓度
200 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2746207
靶标信息
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha E-catenin; alpha-E-catenin; Cadherin-associated protein; catenin (cadherin-associated protein), alpha 1, 102kDa; Catenin alpha-1; Renal carcinoma antigen NY-REN-13
基因别名: CAP102; CTNNA1; MDPT2
UniProt ID: (Human) P35221
Entrez Gene ID: (Human) 1495
ovarian follicle development
actin filament organization
cell adhesion
establishment or maintenance of cell polarity
negative regulation of neuroblast proliferation
aging
male gonad development
gap junction assembly
axon regeneration
adherens junction organization
cellular protein localization
odontogenesis of dentin-containing tooth
apical junction assembly
response to estrogen
positive regulation of smoothened signaling pathway
positive regulation of muscle cell differentiation
protein heterooligomerization
cellular response to indole-3-methanol
epithelial cell-cell adhesion
negative regulation of cell motility
negative regulation of integrin-mediated signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
