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Invitrogen
Cathepsin L Monoclonal Antibody (204101)
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
图: 1 / 8
Cathepsin L Antibody (MA5-23891) in IHC (P)
Immunohistochemical analysis of Cathepsin L in immersion fixed paraffin-embedded sections of human kidney. Samples were incubated in Cathepsin L monoclonal antibody (Product # MA5-23891) using a dilution of 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Rat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in tub... View More
产品信息
MA5-23891
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
204101
抗原
Mouse myeloma cell line NS0-derived recombinant human Cathepsin L Glu113-Val333
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2609641
产品详细信息
In direct ELISAs and Western blots, no cross-reactivity with recombinant human Cathepsin B, C, L2, O, S, or X/Z/P is observed. In Western blots, both the pro and active forms of recombinant human and mouse Cathspsin L are recognized.
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Cat L; Cathepsin L1; furless; Major excreted protein; MEP; nackt; p39 cysteine proteinase; Procathepsin L
基因别名: 1190035F06Rik; CATL; CTSL; CTSL1; fs; MEP; nkt
UniProt ID: (Human) P07711, (Mouse) P06797
Entrez Gene ID: (Human) 1514, (Mouse) 13039
fibronectin binding
cysteine-type endopeptidase activity
serine-type endopeptidase activity
protein binding
collagen binding
cysteine-type peptidase activity
histone binding
proteoglycan binding
serpin family protein binding
aminopeptidase activity
peptidase activity
hydrolase activity
cysteine-type carboxypeptidase activity
kininogen binding
protein complex binding
peptide binding
cysteine protease
toll-like receptor signaling pathway
adaptive immune response
proteolysis
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
extracellular matrix disassembly
collagen catabolic process
proteolysis involved in cellular protein catabolic process
macrophage apoptotic process
cellular response to thyroid hormone stimulus
cell communication
negative regulation of keratinocyte proliferation
protein processing
protein autoprocessing
hair follicle morphogenesis
catagen
decidualization
epithelial tube branching involved in lung morphogenesis
regulation of actin cytoskeleton reorganization
