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Caveolin 3 Antibody (MA5-42865) in IHC (P)
Immunohistochemistry analysis of Caveolin 3 in paraffin-embedded mouse lung. Samples were incubated with Caveolin 3 Monoclonal antibody (Product # MA5-42865) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
MA5-42865
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
4G5W2
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-151 of human Caveolin-3 (P56539)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2912006
产品详细信息
Positive test controls include: Mouse lung, Mouse heart, Rat heart. The target is usually found in the following locations: Cell membrane, Golgi apparatus membrane, Membrane, Peripheral membrane protein, caveola.
Immunogen sequence: MMAEEHTDLE AQIVKDIHCK EIDLVNRDPK NINEDIVKVD FEDVIAEPVG TYSFDGVWKV SYTTFTVSKY WCYRLLSTLL GVPLALLWGF LFACISFCHI WAVVPCIKSY LIEIQCISHI YSLCIRTFCN PLFAALGQVC SSIKVVLRKE V
靶标信息
Caveolin-3 (CAV3) acts as a scaffolding protein within the caveolar membrane. It interacts directly with G-protein alpha subunits and can functionally regulate their activity. Caveolin-3 may also regulate voltage-gated potassium channels. It also plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Caveolin-3 also mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. Mutations in the gene can result in HyperCKmia, rippling muscle disease 2, cardiomyopathy, long QT syndrome 9, sudden infant death syndrome, and myopathy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CAV; Caveolin-3; M-caveolin; MGC126100; MGC126101; MGC126129
基因别名: AI385751; Cav-3; CAV3; LGMD1C; LQT9; M-cav; VIP-21; VIP21
UniProt ID: (Human) P56539, (Rat) P51638, (Mouse) P51637
Entrez Gene ID: (Human) 859, (Rat) 29161, (Mouse) 12391
calcium channel regulator activity
protein binding
protein C-terminus binding
sodium channel regulator activity
potassium channel inhibitor activity
protein complex binding
protein complex scaffold
alpha-tubulin binding
ion channel binding
nitric-oxide synthase binding
connexin binding
enzyme binding
scaffold/adaptor protein
plasma membrane repair
regulation of heart rate
negative regulation of protein kinase activity
triglyceride metabolic process
endocytosis
muscle contraction
plasma membrane organization
actin filament organization
positive regulation of cytosolic calcium ion concentration
muscle organ development
myoblast fusion
regulation of heart contraction
protein localization
positive regulation of cell proliferation
negative regulation of cardiac muscle hypertrophy
positive regulation of myotube differentiation
regulation of skeletal muscle contraction
cell growth
regulation of transforming growth factor beta receptor signaling pathway
cell differentiation
positive regulation of microtubule polymerization
cytoplasmic microtubule organization
membrane raft organization
T-tubule organization
detection of muscle stretch
regulation of signal transduction by receptor internalization
regulation of membrane potential
glucose homeostasis
cholesterol homeostasis
negative regulation of MAP kinase activity
negative regulation of MAPK cascade
negative regulation of cell size
muscle cell cellular homeostasis
negative regulation of nitric-oxide synthase activity
regulation of nerve growth factor receptor activity
nucleus localization
regulation of protein kinase B signaling
negative regulation of calcium ion transport
cardiac muscle cell development
regulation of cardiac muscle contraction
negative regulation of sarcomere organization
regulation of ventricular cardiac muscle cell membrane repolarization
heart trabecula formation
regulation of ventricular cardiac muscle cell membrane depolarization
regulation of branching involved in mammary gland duct morphogenesis
negative regulation of cell growth involved in cardiac muscle cell development
caveola assembly
protein localization to plasma membrane
ventricular cardiac muscle cell action potential
establishment of protein localization to plasma membrane
regulation of calcium ion import
regulation of p38MAPK cascade
regulation of membrane depolarization during cardiac muscle cell action potential
negative regulation of membrane depolarization during cardiac muscle cell action potential
negative regulation of potassium ion transmembrane transporter activity
regulation of calcium ion transmembrane transporter activity
negative regulation of potassium ion transmembrane transport
negative regulation of protein localization to cell surface
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of sodium ion transmembrane transporter activity
positive regulation of caveolin-mediated endocytosis
myotube differentiation
regulation of calcium ion transport
