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Cdc14B Antibody (34-8900) in ICC/IF
Immunofluorescent staining of U2OS or HeLa cells with Rb anti-CDC14B (green) (Product # 34-8900). DNA is labeled with DAPI (blue), anti-CDC14B is labeled with FITC (green), and anti-Tubulin is labeled with rhodamine (red). CDC14B appears as bright nuclear dots and midbodies of cells undergoing cytokinesis. Image courtesy of Dr. Catherine Regnard and Dr. Ulrike Grueneberg, Max Planck Institute for Biochemistry, Germany.
产品信息
34-8900
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from the N-terminal region of the human Cdc14B protein.
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.1% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2533189
靶标信息
CDC14B is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CDC14 cell division cycle 14 homolog B; Dual specificity protein phosphatase CDC14B
基因别名: 2810432N10Rik; A530086E13Rik; AA472821; CDC14B; Cdc14B1; Cdc14B2; CDC14B3; hCDC14B
UniProt ID: (Human) O60729, (Mouse) Q6PFY9
Entrez Gene ID: (Human) 8555, (Mouse) 218294
