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Invitrogen
Cdc73 Recombinant Rabbit Monoclonal Antibody (23GB3450)
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
图: 1 / 4
Cdc73 Antibody (MA5-53424) in ICC/IF
Immunocytochemistry analysis of CDC73 in C2C12 cells. Nuclei were stained blue with DAPI; CDC73 recombinant monoclonal antibody (Product # MA5-53424) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar: 20 μm.
产品信息
MA5-53424
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
23GB3450
抗原
A synthetic peptide of human HRPT2/CDC73 (350-400AA).
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
靶标信息
Cdc73 is a tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. Cdc73 is part of the PAF1 complex, a five-subunit protein complex composed of Paf1, Cdc73, Leo1, Rtf1 and Ctr9. PAF1 was first purified from yeast in association with RNA polymerase II and is believed to function in transcription elongation. The yeast PAF (yPAF) complex interacts with RNA polymerase II and coordinates the setting of histone marks associated with active transcription. In addition to coordinating events during transcription (initiation, promoter clearance, and elongation), hPAF also coordinates events in RNA quality control. Cdc73 may also be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cell division cycle 73 Paf1/RNA polymerase II complex component-like protein; cell division cycle 73, Paf1/RNA polymerase II complex component, homolog; Cell division cycle protein 73 homolog; hyperparathyroidism 2 (with jaw tumor); hyperparathyroidism 2 homolog; Hyperparathyroidism 2 protein; Hyperparathyroidism 2 protein homolog; Paf1/RNA polymerase II complex component; Parafibromin; Vcell division cycle 73, Paf1/RNA polymerase II complex component, homolog
基因别名: 8430414L16Rik; BC027756; C130030P16Rik; C1orf28; C81219; CDC73; FIHP; HPTJT; HRPT1; HRPT2; HYX
UniProt ID: (Human) Q6P1J9, (Mouse) Q8JZM7, (Rat) Q4V8C8
Entrez Gene ID: (Human) 79577, (Mouse) 214498, (Rat) 304832
negative regulation of transcription from RNA polymerase II promoter
endodermal cell fate commitment
transcription, DNA-templated
mRNA polyadenylation
cell cycle
negative regulation of cell proliferation
histone monoubiquitination
Wnt signaling pathway
stem cell population maintenance
positive regulation of Wnt signaling pathway
positive regulation of mRNA 3'-end processing
protein destabilization
positive regulation of transcription elongation from RNA polymerase II promoter
histone H2B ubiquitination
negative regulation of myeloid cell differentiation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of fibroblast proliferation
negative regulation of epithelial cell proliferation
cellular response to lipopolysaccharide
negative regulation of G1/S transition of mitotic cell cycle
transcription elongation from RNA polymerase II promoter
beta-catenin-TCF complex assembly
biological_process
