Invitrogen

Collagen IV Polyclonal Antibody

Collagen IV Antibody in Western Blot (WB)

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Collagen IV Antibody (PA5-104508) in WB

Western blot analysis of Collagen IV in 293 and HeLa (Lane 1: 293 cells, Lane 2: Hela cells, Lane 3: 293 cells treated with blocking peptide). Samples were incubated with Collagen IV polyclonal antibody (Product # PA5-104508).

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产品信息

PA5-104508

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:200

免疫细胞化学 (ICC/IF)

1:100-1:500

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human COL4A1(Accession P02462), corresponding to amino acid residues A27-Q77.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2853809

产品详细信息

Antibody detects endogenous levels of total Collagen IV.

靶标信息

Collagen IV is a type of collagen protein that is a major component of the basement membrane in various tissues, including the kidneys, lungs, and skin. It forms a network-like structure that provides support and stability to the surrounding tissue. Collagen IV is composed of three alpha chains, which are encoded by the COL4A1, COL4A2, and COL4A3 genes. Mutations in these genes can lead to various genetic disorders, such as Alport syndrome and Goodpasture syndrome, which affect the kidneys and lungs, respectively.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Restoration of renal TIMP3 levels via genetics and pharmacological approach prevents experimental diabetic nephropathy.

Clinical and translational medicine

Casagrande V,Iuliani G,Menini S,Pugliese G,Federici M,Menghini R

Published figure using Collagen IV polyclonal antibody (Product # PA5-104508) in Western Blot

Mon Feb 01 00:00:00 EST 2021

Mouse models for dominant dystrophic epidermolysis bullosa carrying common human point mutations recapitulate the human disease.

Disease models & mechanisms

Smith BRC,Nyström A,Nowell CJ,Hausser I,Gretzmeier C,Robertson SJ,Varigos GA,Has C,Kern JS,Pang KC

PA5-104508 was used in Western Blot to develop a mouse model for dominant dystrophic epidermolysis bullosa using a CRISPR-Cas9 system utilising two common disease mutations.

Tue Jun 01 00:00:00 EDT 2021

Mouse models for dominant dystrophic epidermolysis bullosa carrying common human point mutations recapitulate the human disease.

Disease models & mechanisms

Smith BRC,Nyström A,Nowell CJ,Hausser I,Gretzmeier C,Robertson SJ,Varigos GA,Has C,Kern JS,Pang KC

PA5-104508 was used in Western Blot to develop a mouse model for dominant dystrophic epidermolysis bullosa using a CRISPR-Cas9 system utilising two common disease mutations.

Tue Jun 01 00:00:00 EDT 2021

生物信息学

蛋白别名: alpha 1 type IV collagen; alpha-2 collagen type IV; alpha1(IV) collagen; arresten; canstatin; COL4A1 NC1 domain; col4a3; col4a4; Collagen 4; Collagen alpha-1(IV) chain; Collagen alpha-2(IV) chain; Collagen alpha-3(IV) chain; Collagen alpha-4(IV) chain; Collagen alpha-5(IV) chain; Collagen alpha-6(IV) chain; collagen IV, alpha-1 polypeptide; collagen IV, alpha-3 polypeptide; Collagen IV, alpha-4 polypeptide; collagen IV, alpha-5 polypeptide; collagen IV, alpha-6 polypeptide; collagen of basement membrane, alpha-1 chain; collagen of basement membrane, alpha-4 chain; collagen of basement membrane, alpha-5 chain; collagen of basement membrane, alpha-6; collagen type IV alpha3 chain; collagen type IV alpha5 chain; collagen, type IV, alpha 1; collagen, type IV, alpha 3 (Goodpasture antigen); collagen, type IV, alpha 4; collagen, type IV, alpha 5; collagen, type IV, alpha 6; dA149D17.3; dA24A23.1; Del(8)Bru44H; dJ889N15.4 (Collagen Alpha 6(IV)); Goodpasture antigen; procollagen type IV alpha 5; procollagen type IV alpha 6; procollagen, type IV, alpha 1; procollagen, type IV, alpha 2; procollagen, type IV, alpha 3; procollagen, type IV, alpha 4; procollagen, type IV, alpha 5; procollagen, type IV, alpha 6; retinal anterior wiring; tumstatin; Type IV Collagen

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基因别名: [a]3(IV); [a]4(IV); alpha3(IV); ASLN; ATS; BB116301; Bru; BSVD; CA44; CA54; Col4a-1; Col4a-2; COL4A1; COL4A2; COL4A3; COL4A4; COL4A5; COL4A6; CXDELq22.3; Del(8)44H; DELXq22.3; DFNX6; E130010M05Rik; ICH; POREN2; RATOR; Raw; RGD1565499; Svc

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功能

extracellular matrix structural constituent protein binding extracellular matrix constituent conferring elasticity platelet-derived growth factor binding integrin binding structural molecule activity metalloendopeptidase inhibitor activity molecular_function extracellular matrix structural protein extracellular matrix protein

参与通路

patterning of blood vessels brain development neuromuscular junction development extracellular matrix organization collagen catabolic process epithelial cell differentiation blood vessel morphogenesis retinal blood vessel morphogenesis renal tubule morphogenesis cellular response to amino acid stimulus basement membrane organization activation of cysteine-type endopeptidase activity involved in apoptotic process cell adhesion cell surface receptor signaling pathway sensory perception of sound blood circulation cell proliferation negative regulation of cell proliferation negative regulation of endopeptidase activity negative regulation of angiogenesis glomerular basement membrane development endothelial cell apoptotic process angiogenesis transcription, DNA-templated endodermal cell differentiation cellular response to transforming growth factor beta stimulus response to glucose biological_process

Collagen IV Polyclonal Antibody

Collagen IV Antibody (PA5-104508) in WB

产品信息

PA5-104508

免疫印迹 (WB)

免疫组化（石蜡） (IHC (P))

免疫细胞化学 (ICC/IF)

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID

产品详细信息

靶标信息

生物信息学

性能保障

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