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Connexin-40 (GJA5) Antibody (ACC-205-200UL) in WB
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) heart lysates: - 1,2. Anti-Connexin-40 (GJA5) Antibody (#ACC-205), (1:200).3,4. Anti-Connexin-40 (GJA5) Antibody , preincubated with Connexin-40/GJA5 Blocking Peptide (#BLP-CC205).
产品信息
ACC-205-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)GHRFPQGYHSDKR, corresponding to amino acid residues 328-340 of rat Connexin-40, Intracellular, C-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Connexin 40 (Cx40), belongs to the connexin family of gap junction proteins, which are expressed in pancreas, kidney, skeletal muscle, liver, placenta and heart. Connexin 40 is highly expressed in vascular endothelial cells, and the mammalian heart (specifically in the atrial myocardium, and the His-Purkinje conduction system). At least three other connexins are expressed in the heart, including Cx37 (endocardium), Cx43 (atrial and ventricular myocardium, and distal parts of the conduction system) and Cx45 (throughout the heart). Cx40 and Cx43 frequently co-localize in cells of the cardiovascular system and participate in the formation of heterotypic gap junction channels.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: connexin 40; Connexin-40; Cx40; Gap junction alpha-5 protein; gap junction membrane channel protein alpha 5
基因别名: 5730555N10Rik; Cnx40; Cx40; Cxn-40; Gja-5; Gja5
UniProt ID: (Rat) P28234, (Mouse) Q01231
Entrez Gene ID: (Rat) 50563, (Mouse) 14613
skeletal system development
angiogenesis
blood vessel development
renal system process involved in regulation of systemic arterial blood pressure
regulation of systemic arterial blood pressure
negative regulation of glomerular filtration
outflow tract morphogenesis
endothelium development
cardiac conduction system development
mitral valve development
pulmonary valve formation
ventricular septum development
atrial septum development
septum primum development
atrial ventricular junction remodeling
potassium ion transport
heart development
cell communication by chemical coupling
cell communication by electrical coupling
positive regulation of cell communication by chemical coupling
gap junction assembly
embryonic limb morphogenesis
embryonic heart tube development
foramen ovale closure
regulation of vasodilation
negative regulation of blood pressure
positive regulation of vasoconstriction
positive regulation of vasodilation
artery morphogenesis
protein oligomerization
transmembrane transport
regulation of cardiac muscle contraction
regulation of ventricular cardiac muscle cell membrane repolarization
regulation of atrial cardiac muscle cell membrane depolarization
regulation of ventricular cardiac muscle cell membrane depolarization
ventricular septum morphogenesis
atrial septum morphogenesis
cardiac conduction
ventricular cardiac muscle cell action potential
atrial cardiac muscle cell action potential
SA node cell action potential
AV node cell to bundle of His cell communication by electrical coupling
cell communication by electrical coupling involved in cardiac conduction
cell communication involved in cardiac conduction
AV node cell to bundle of His cell communication
bundle of His cell to Purkinje myocyte communication
regulation of heart rate by cardiac conduction
regulation of renin secretion into blood stream
regulation of membrane depolarization during cardiac muscle cell action potential
vasomotion
cell communication
bundle of His cell to Purkinje myocyte communication by electrical coupling
regulation of AV node cell action potential
regulation of bundle of His cell action potential
regulation of Purkinje myocyte action potential
regulation of atrial cardiac muscle cell action potential
