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Contactin 2 Antibody (PA5-121133) in WB
Western blot analysis of Contactin 2 in extracts of various cell lines. Samples were incubated with Contactin 2 Polyclonal antibody (Product # PA5-121133) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
PA5-121133
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 785-1012 of human Contactin 2 (NP_005067.1).
偶联物
形式
Liquid
浓度
1.37 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914705
产品详细信息
Positive test controls include: Mouse brain, Mouse spinal cord, Rat brain. The target is usually found in the following locations: Cell membrane, GPI-anchor, Lipid-anchor.
Immunogen sequence: EVKIRSYNRR GDGPESLTAL VYSAEEEPRV APTKVWAKGV SSSEMNVTWE PVQQDMNGIL LGYEIRYWKA GDKEAAADRV RTAGLDTSAR VSGLHPNTKY HVTVRAYNRA GTGPASPSAN ATTMKPPPRR PPGNISWTFS SSSLSIKWDP VVPFRNESAV TGYKMLYQND LHLTPTLHLT GKNWIEIPVP EDIGHALVQI RTTGPGGDGI PAEVHIVRNG GTSMMVEN
靶标信息
Contactin 2 (CNTN2, transiently-expressed axonal glycoprotein, AXT, TAX, TAX1, TAG-1, axonin 1) is a neuronal cell adhesion molecule (CAM) that influences the formation of axon connections in the developing nervous system. Contactin 2 is a member of the immunoglobulin superfamily (IgSF) and contains a glycosylphosphatidylinositol-anchor, six immunoglobulin (Ig)-like and four Fibronectin type III (FNIII)-like domains. Contactin 2 is expressed predominantly during neural development on the cell membrane of axons in nerve fiber tracts in order to guide commissural axons without promoting their growth. Contactin 2 binds with NgCAM in the plane of the same membrane (cis-binding). The Contactin 2 heterophilic (Contactin 2/NgCAM and Contactin 2/NrCAM) binding sites are localized to the first four Ig domains. The Contactin 2 homophilic (Contactin 2/Contactin 2) binding site is localized to the FNIII domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Axonal glycoprotein TAG-1; axonin; Axonin 1; Axonin-1; Axonin1; Contactin-2; Contactin2; DKFZp781D102; MGC157722; TAX-1; Transient axonal glycoprotein 1; transiently-expressed axonal glycoprotein
基因别名: Cntn2; D130012K04Rik; TAG-1; TAG-564; TAG1; Tax; Tax1
UniProt ID: (Mouse) Q61330, (Rat) P22063
Entrez Gene ID: (Mouse) 21367, (Rat) 25356
microtubule cytoskeleton organization
neuron migration
cell adhesion
cell-matrix adhesion
axonogenesis
axon guidance
axonal fasciculation
learning
adult walking behavior
regulation of cell morphogenesis involved in differentiation
positive regulation of protein processing
cerebral cortex GABAergic interneuron migration
central nervous system myelination
regulation of axon diameter
neuron projection development
receptor internalization
clustering of voltage-gated potassium channels
negative regulation of neuron differentiation
regulation of neuronal synaptic plasticity
regulation of astrocyte differentiation
positive regulation of adenosine receptor signaling pathway
protein localization to juxtaparanode region of axon
establishment of protein localization to juxtaparanode region of axon
presynaptic membrane organization
cellular protein localization
