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产品信息
PA5-120103
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 468-768 of human Cullin 3 (NP_0035811)
偶联物
形式
Liquid
浓度
1.41 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2913675
产品详细信息
Positive test controls include: SH-SY5Y, Mouse brain. The target is usually found in the following locations: Golgi apparatus, Nucleus.
Immunogen sequence: SKLEGMFRDM SISNTTMDEF RQHLQATGVS LGGVDLTVRV LTTGYWPTQS ATPKCNIPPA PRHAFEIFRR FYLAKHSGRQ LTLQHHMGSA DLNATFYGPV KKEDGSEVGV GGAQVTGSNT RKHILQVSTF QMTILMLFNN REKYTFEEIQ QETDIPEREL VRALQSLACG KPTQRVLTKE PKSKEIENGH IFTVNDQFTS KLHRVKIQTV AAKQGESDPE RKETRQKVDD DRKHEIEAAI VRIMKSRKKM QHNVLVAEVT QQLKARFLPS PVVIKKRIEG LIEREYLART PEDRKVYTYV A
靶标信息
Cullin 3 is a member of the family of human cullin genes (CUL 1, 2, 3, 4a, 4b, and 5) homologous to the S. cerevisiae cdc 53 gene. CUL 1 forms a complex with human p19 skp1 and F box protein p45 skp2. Together with cdc 53 (Known as Cul A), as three subunits, they form a ubiquitin ligase-controlling proteolysis of G1 cell cycle regulatory proteins. In contrast to CUL 1, CUL 2 does not associate with p19 skp1 and p45 skp2. Instead, CUL 2 forms a complex with an inactive transcriptional elongation complex, SIII, formed by three subunits: Elongain C, Elongin B and VHL. The function of this association remains unknown.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CUL-3; Cullin-3; OTTHUMP00000203839; OTTHUMP00000203840
基因别名: AI467304; AW146203; CUL-3; CUL3; KIAA0617; mKIAA0617; PHA2E
UniProt ID: (Human) Q13618, (Mouse) Q9JLV5
Entrez Gene ID: (Human) 8452, (Mouse) 26554, (Rat) 301555
G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
protein polyubiquitination
trophectodermal cellular morphogenesis
protein monoubiquitination
ER to Golgi vesicle-mediated transport
cell cycle arrest
mitotic metaphase plate congression
integrin-mediated signaling pathway
gastrulation
negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation
positive regulation of cell proliferation
Wnt signaling pathway
cell migration
protein ubiquitination
stem cell division
cell projection organization
positive regulation of cytokinesis
negative regulation of Rho protein signal transduction
embryonic cleavage
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
stress fiber assembly
proteasome-mediated ubiquitin-dependent protein catabolic process
fibroblast apoptotic process
positive regulation of mitotic metaphase/anaphase transition
COPII vesicle coating
liver morphogenesis
negative regulation of canonical Wnt signaling pathway
intrinsic apoptotic signaling pathway
mitotic cell cycle
cell morphogenesis
in utero embryonic development
regulation of transcription from RNA polymerase II promoter
ubiquitin-dependent protein catabolic process
transport
vesicle-mediated transport
biological_process
