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Immunogen sequence: METGFPAIMY PGSFIGGWGE EYLSWEGPGL PDFVFQQPVE SEAMHCSNPK SGVVLATVAR GPDACQILTR APLGQDPPQR TVLGLLTANG QYRRTCGQGI TRIRCYSGSE NAFPPAGKKA LPDCGVQEPP KQGFDIYMDE LEQGDRDSCS VREGMAFEDV YEVDTGTLKS DLHFLLDFNT VSPMLVDSSL LSQSEDISSL GTDVINVTEY AEEIYQYLRE AEIRHRPKAH
The critical role that the family of regulatory proteins known as cyclins play in eukaryotic cell cycle regulation is well established. The best-characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase, the active component of maturing promoting factor. Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin-dependent kinase-2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DRTF1 and E2F and retinoblastoma protein, p110. A second form of cyclin A, named cyclin A1 because of its high sequence homology to Xenopus cyclin A1, is most highly expressed in germ cells. It has been proposed that cyclin A1 can associate with Cdk2, p39 and Cdc2 p34.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cyclin A; Cyclin-A; Cyclin-A1; Cyclin-A2; CyclinA; CyclinA1; testicular tissue protein Li 34
基因别名: CCN1; CCNA; CCNA1; CCNA2; CT146
UniProt ID: (Human) P78396, (Human) P20248, (Rat) Q6AY13
Entrez Gene ID: (Human) 8900, (Human) 890, (Rat) 295052, (Rat) 114494
分子生物学功能:
kinase activator