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Invitrogen
Cyclin T1 Polyclonal Antibody
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
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Cyclin T1 Antibody (PA5-82177)
Antibody specificity was demonstrated by siRNA mediated knockdown of target protein. HeLa cells were transfected with, control siRNA, Cyclin T1 siRNA probe #1, and Cyclin T1 siRNA probe #2 and a decrease in signal intensity was observed in Western Blot application using anti-Cyclin T1 Polyclonal Antibody (Product # PA5-82177) used at a dilution of 0.4 µg/mL. Anti-CCNT1 was used as a loading control. {KD}
产品信息
PA5-82177
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Anitgen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2789338
产品详细信息
Immunogen sequence: KTSEQTILNM ISQSSSDTTI AGLMSMSTST TSAVPSLPVS EESSSNLTSV EMLPGKRWLS SQPSFKLEPT QGHRTSENLA LTGVDHSLPQ DGSNAFISQK QNSKSVPSAK VSLKEYRAKH AEELAAQKRQ LEN
靶标信息
This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDK9-associated C-type protein; cyclin C-related protein; cyclin T1b; cyclin-T; Cyclin-T1; CycT1; human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1
基因别名: 2810478G24Rik; AI115585; CCNT; CCNT1; CYCT1; HIVE1
UniProt ID: (Human) O60563, (Mouse) Q9QWV9
Entrez Gene ID: (Human) 904, (Rat) 315291, (Mouse) 12455
DNA binding
chromatin binding
protein serine/threonine kinase activity
protein binding
transcription factor binding
cyclin-dependent protein serine/threonine kinase regulator activity
transcription regulatory region DNA binding
RNA polymerase binding
7SK snRNA binding
molecular_function
snRNA binding
protein kinase binding
kinase activator
regulation of cyclin-dependent protein serine/threonine kinase activity
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
protein phosphorylation
cell cycle
viral process
snRNA transcription from RNA polymerase II promoter
positive regulation by host of viral transcription
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of viral transcription
cell division
negative regulation of mRNA polyadenylation
positive regulation of phosphorylation of RNA polymerase II C-terminal domain
transcription, DNA-templated
regulation of transcription, DNA-templated
biological_process
response to drug
