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Cyclophilin B Antibody (PA1-027A-A555) in ICC/IF
Immunofluorescent analysis of Cyclophilin B (orange) in HeLa cells. The cells were fixed with 4% Paraformaldehyde in PBS for 15 minutes at room temperature, and blocked with 3% BSA in PBS (Product # 37525) for 30 minutes at room temperature. Cells were stained with a Cyclophilin B Polyclonal Antibody, AlexaFluor 555 conjugate (Product # PA1-027A-A555) at a dilution of 2.5 µg/mL in blocking buffer for 1 hour... View More
产品信息
PA1-027A-A555
产品规格
种属反应
Dog,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues C(194) G K I E V E K P F A I A K E(208) of human CyPB
偶联物
激发/发射光谱
553/568 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2662703
产品详细信息
PA1027AA555 detects cyclophilin B (CyPB) in mouse, rat, canine, and human tissues.
The PA1027AA555 immunogen is a synthetic peptide corresponding to residues C(194) G K I E V E K P F A I A K E(208) of human CyPB. This sequence is almost completely conserved between human, mouse, rat, bovine, and chicken. PA1027AA555 immunizing peptide (Cat. # PEP-058) is available for use in neutralization and control experiments.
靶标信息
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cyclophilin B; cyclophilin-like protein; Cyp B; CYP-S1; EC 5.2.1.8; epididymis secretory protein Li 39; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase B; Rotamase B; S-cyclophilin; S-cyclophylin; SCYLP
基因别名: AA408962; AA553318; AI844835; Cphn-2; Cphn2; CyP-20b; CYP-S1; CYPB; HEL-S-39; OI9; PPIB; SCYLP
UniProt ID: (Human) P23284, (Rat) P24368, (Mouse) P24369
Entrez Gene ID: (Dog) 478337, (Human) 5479, (Rat) 64367, (Mouse) 19035
protein peptidyl-prolyl isomerization
positive regulation of multicellular organism growth
positive regulation by host of viral process
positive regulation by host of viral genome replication
protein stabilization
bone development
chaperone-mediated protein folding
regulation of post-translational protein modification
nuclear transport
protein folding
