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Cytokeratin 5 Antibody (MA5-33066) in IHC (P)
Immunohistochemistry (paraffin) analysis of Cytokeratin 5 in formalin fixed and paraffin embedded human Lung Squamous Cell Carcinoma tissue, using Cytokeratin 5 Recombinant Monoclonal antibody (Product # MA5-33066) at a dilution of 1:200.
产品信息
MA5-33066
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
RM226
抗原
A peptide corresponding to the C-terminus of Human Cytokeratin 5.
偶联物
Unconjugated
形式
Liquid
浓度
0.04 mg/mL
纯化类型
Protein A
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2810159
产品详细信息
Specificity: reacts to human CK-5 (Cytokeratin 5), and does not cross-react to CK-6 (Cytokeratin 6). Specificity: may also react to bovine, mouse, or rat Cytokeratin, as predicted by immunogen homology.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 58 kDa cytokeratin; CK-5; Cytokeratin-5; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; Keratin, type II cytoskeletal 5; Keratin-5; Type-II keratin Kb5
基因别名: CK5; DDD; DDD1; EBS2; K5; KRT5; KRT5A
UniProt ID: (Human) P13647
Entrez Gene ID: (Human) 3852
