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D4 Dopamine Receptor Antibody (PA5-89196) in IHC (P)
Immunohistochemistry analysis of D4 Dopamine Receptor in paraffin-embedded rat retina. Samples were incubated with D4 Dopamine Receptor Polyclonal antibody (Product # PA5-89196) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-89196
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human DRD4 (NP_0007882)
偶联物
形式
Liquid
浓度
1.27 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805410
产品详细信息
Immunogen sequence: AWLLSPRLCD ALMAMDVMLC TASIFNLCAI SVDRFVAVAV PLRYNRQGGS RRQLLLIGAT WLLSAAVAAP VLCGLNDVRG RDPAVCRLED RDYVVYSSVC S; Positive Samples: Mouse brain, Rat brain; Cellular Location: Cell membrane, Multi-pass membrane protein
靶标信息
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: D(2C) dopamine receptor; D(4) dopamine receptor; Dopamine 4 receptor; Dopamine D4 receptor; dopamine receptor 4
基因别名: AW125663; D4R; D4RA; Drd-4; Drd4
UniProt ID: (Mouse) P51436
Entrez Gene ID: (Rat) 25432, (Mouse) 13491
dopamine neurotransmitter receptor activity, coupled via Gi/Go
dopamine neurotransmitter receptor activity
protein binding
drug binding
SH3 domain binding
dopamine binding
identical protein binding
signal transducer activity
G-protein coupled receptor activity
G-protein coupled amine receptor activity
G-protein coupled receptor
activation of MAPK activity
behavioral fear response
synaptic transmission, dopaminergic
response to amphetamine
negative regulation of adenylate cyclase activity
adenylate cyclase-inhibiting dopamine receptor signaling pathway
dopamine receptor signaling pathway
short-term memory
circadian rhythm
locomotory behavior
associative learning
adult locomotory behavior
olfactory learning
photoperiodism
negative regulation of cAMP biosynthetic process
positive regulation of sodium:proton antiporter activity
positive regulation of kinase activity
response to histamine
regulation of dopamine metabolic process
fear response
regulation of circadian rhythm
regulation of neurotransmitter secretion
behavioral response to cocaine
response to steroid hormone
arachidonic acid secretion
negative regulation of protein secretion
modulation of synaptic transmission
regulation of calcium-mediated signaling
retina development in camera-type eye
inhibitory postsynaptic potential
positive regulation of penile erection
negative regulation of voltage-gated calcium channel activity
positive regulation of excitatory postsynaptic potential
signal transduction
G-protein coupled receptor signaling pathway
chemical synaptic transmission
sensory perception of chemical stimulus
rhythmic process
