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Suggested positive control for Western blot is 293 cells transfected with Dab1 HA tag and for immunoprecipitation is Dab1 knockout brain p14 lysated and Dab1 wild type brain p14 lysate. PA1-21178 detects a band of approximately 80 kDa.
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Disabled homolog 1; mDab1; RP23-356E21.1; yotari
基因别名: AI956902; C630028C02Rik; Dab1; scm; scr; scrambler; yot
UniProt ID: (Mouse) P97318
Entrez Gene ID: (Mouse) 13131