Invitrogen

DAB2 Polyclonal Antibody

查看其他10个DAB2抗体

抗体检测数据 (1)

DAB2 Antibody in Western Blot (WB)

DAB2 Antibody in Western Blot (WB)

图: 1 / 1

DAB2 Antibody (PA5-49237) in WB

Western blot analysis of DAB2 in mouse NIH-3T3 cell line lysates. Samples were incubated with DAB2 polyclonal antibody (Product # PA5-49237). Lysates: 35 µg/lane. Mouse Dab2 protein (arrow).

DAB2 Antibody in Western Blot (WB)

Product Image Gallery

DAB2 Antibody in Western Blot (WB) — Western blot analysis of DAB2 in mouse NIH-3T3 cell line lysates. Samples were incubated with DAB2 polyclonal antibody (Product # PA5-49237). Lysates: 35 µg/lane. Mouse Dab2 protein (arrow).

产品信息

PA5-49237

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

-

产品规格

种属反应

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 624-650 amino acids from the C-terminal region of mouse Dab2.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A, Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2634693

产品详细信息

Predicted to react with rat based on sequence homology.

靶标信息

DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。

引用该产品

生物信息学

蛋白别名: Adaptor molecule disabled-2; Differentially expressed in ovarian carcinoma 2; Disabled homolog 2; DOC-2; FLJ26626; Mitogen-responsive phosphoprotein

查看更多收起

基因别名: 5730435J12Rik; AA960054; AI957090; D15Wsu122e; D630005B22Rik; Dab2; Doc-2; Doc2; p96

查看更多收起

UniProt ID: (Mouse) P98078

查看更多收起

Entrez Gene ID: (Mouse) 13132

查看更多收起

integrin binding protein binding phosphatidylinositol-4,5-bisphosphate binding protein C-terminus binding clathrin binding phosphatidylinositol binding AP-2 adaptor complex binding clathrin adaptor activity cargo receptor activity SMAD binding scaffold/adaptor protein

参与通路

cell morphogenesis involved in differentiation in utero embryonic development positive regulation of receptor recycling positive regulation of protein phosphorylation transport endocytosis receptor-mediated endocytosis pinocytosis apoptotic process activation of JUN kinase activity multicellular organism development endoderm development excretion positive regulation of epithelial to mesenchymal transition positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of neuron projection development protein transport Wnt signaling pathway cell differentiation negative regulation of cell growth positive regulation of cell migration positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of protein binding positive regulation of aldosterone biosynthetic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of transcription elongation from RNA polymerase II promoter leading edge cell differentiation negative regulation of apoptotic process positive regulation of cell adhesion positive regulation of endocytosis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated clathrin coat assembly response to steroid hormone negative regulation of epithelial cell proliferation positive regulation of SMAD protein import into nucleus negative regulation of androgen receptor signaling pathway negative regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus cellular response to transforming growth factor beta stimulus negative regulation of canonical Wnt signaling pathway positive regulation of substrate adhesion-dependent cell spreading negative regulation of protein localization to plasma membrane positive regulation of Wnt signaling pathway, planar cell polarity pathway regulation of Rho-dependent protein serine/threonine kinase activity positive regulation of clathrin-mediated endocytosis positive regulation of early endosome to late endosome transport positive regulation of aldosterone secretion positive regulation of integrin-mediated signaling pathway negative regulation of extrinsic apoptotic signaling pathway