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DAZL Antibody (PA5-116570) in IHC (P)
Immunohistochemistry analysis of DAZL in paraffin-embedded mouse testis. Samples were incubated with DAZL Polyclonal antibody (Product # PA5-116570) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
PA5-116570
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 200-250 of human DAZL (NP_0013422)
偶联物
形式
Liquid
浓度
0.71 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901201
产品详细信息
Positive Samples: Mouse testis, Rat testis
Immunogen sequence: QRSYVVPPAY SAVNYHCNEV DPGAEVVPNE CSVHEATPPS GNGPQKKSVD R
靶标信息
Protein expression pattern show that DAZL is involved in mitosis and meiosis of human germ cell. The DAZL gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females.The protein is expressed in germ cells of diverse mammalian species. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In humans, DAZL is expressed in primordial germ cells, adult testis, and the ovary. It plays a central role during spermatogenesis. Defects in DAZL may cause infertility due to severe oligozoospermia (az) and non obstructive azoospermia. The concentrations of DAZL transcripts were lower in men with spermatogenic failure. Drosophila and mouse mutants that have lost DAZ homologous gene function found to be azoospermic, just as with human azoospermia DAZ. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DAZ homolog; DAZ-like autosomal; deleted in azoospermia protein 3; Deleted in azoospermia-like; Deleted in azoospermia-like 1; germline specific RNA binding protein; HGNC:2685; MGC26406; spermatogenesis gene on the Y-like autosomal; SPGY-like-autosomal; testis secretory sperm-binding protein Li 204a
基因别名: Daz-like; DAZH; DAZL; DAZL1; DAZLA; SPGYLA; Tpx-2; Tpx2
UniProt ID: (Human) Q92904, (Mouse) Q64368
Entrez Gene ID: (Human) 1618, (Mouse) 13164, (Rat) 680486
