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DDR2 Antibody (PA5-95551) in IHC (P)
Immunohistochemistry analysis of DDR2 in paraffin-embedded mouse small intestine tissue. Antigen retrieval was performed on the tissue using citrate buffer (pH 6, 20 min) and blocked with 10% goat serum. Samples were incubated with DDR2 polyclonal antibody (Product # PA5-95551) at a 2 µg/mL dilution, followed by biotinylated goat anti-rabbit IgG (30 min, 37°C), and developed with Strepavidin-Biotin-Complex ... View More
产品信息
PA5-95551
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human DDR2 recombinant protein (Position: T801-E855).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2807353
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
DDR2 is a member of a subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. DDR1 and DDR2 have been shown to be potently inhibited by Gleevec. DDR2 required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD167 antigen-like family member B; CD167b; CD167b antigen; CD_antigen: CD167b; cell migration-inducing protein 20; Discoidin domain receptor 2; discoidin domain receptor family, member 2; Discoidin domain-containing receptor 2; Discoidin domain-containing receptor tyrosine kinase 2; hydroxyaryl-protein; hydroxyaryl-protein kinase; migration-inducing gene 16 protein; neurotrophic tyrosine kinase receptor related 3; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; RP11-572K18.1; tyrosine-protein kinase TYRO 10; Tyrosine-protein kinase TYRO10; tyrosylprotein kinase
基因别名: AW495251; DDR2; MIG20a; NTRKR3; TKT; TYRO10
UniProt ID: (Human) Q16832, (Mouse) Q62371
Entrez Gene ID: (Human) 4921, (Mouse) 18214, (Rat) 685781
transmembrane receptor protein tyrosine kinase activity
protein binding
collagen binding
ATP binding
protein tyrosine kinase collagen receptor activity
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
ossification
endochondral bone growth
cell adhesion
signal transduction
regulation of extracellular matrix disassembly
positive regulation of fibroblast migration
peptidyl-tyrosine phosphorylation
extracellular matrix organization
collagen fibril organization
regulation of bone mineralization
biomineral tissue development
chondrocyte proliferation
collagen-activated tyrosine kinase receptor signaling pathway
positive regulation of osteoblast differentiation
positive regulation of protein kinase activity
protein autophosphorylation
positive regulation of fibroblast proliferation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of extracellular matrix disassembly
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
phosphorylation
