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产品信息
PA5-28695
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 352 and 740 of Human DDX1
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546171
产品详细信息
Recommended positive controls: HeLa.
Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (89%), Xenopus laevis (90%), Chicken (94%), Rhesus Monkey (99%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
DDX1 (ATP-dependent RNA helicase DDX1) acts as an ATP-dependent RNA helicase. It is able to unwind both RNA-RNA and RNA-DNA duplexes. DDX1 possesses 5' single-stranded RNA overhand nuclease activity and ATPase activity on various RNA, but not DNA polynucleotides. DDX1, together with RELA, acts as a coactivator to enhance NF-kappa-b-mediated transcriptional activation. It also acts as a positive transcriptional regulator of cyclin CCND2 expression. It binds to the cyclin CCND2 promoter region. DDX1 is a component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double stranded RNA and plays a role in activation of a cascade of antiviral responses including the induction of proinflammatory cytokines via the adapter molecule TICAM1.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-dependent RNA helicase DDX1; DBP-RB; DEAD (Asp-Glu-Ala-Asp) box helicase 1; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD box polypeptide 1; DEAD box protein 1; DEAD box protein retinoblastoma; DEAD box-1; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1
基因别名: DBP-RB; DDX1; UKVH5d
UniProt ID: (Human) Q92499
Entrez Gene ID: (Human) 1653
DNA binding
chromatin binding
transcription cofactor activity
RNA helicase activity
double-stranded RNA binding
ATP-dependent RNA helicase activity
nuclease activity
exonuclease activity
protein binding
ATP binding
ATP-dependent helicase activity
poly(A) binding
DNA/RNA helicase activity
poly(A) RNA binding
spliceosomal complex assembly
double-strand break repair
transcription, DNA-templated
regulation of transcription, DNA-templated
tRNA splicing, via endonucleolytic cleavage and ligation
regulation of translational initiation
multicellular organism development
response to virus
RNA secondary structure unwinding
DNA duplex unwinding
response to exogenous dsRNA
nucleic acid phosphodiester bond hydrolysis
protein localization to cytoplasmic stress granule
