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Immunogen sequence: TLLDESFLEL VDYILEKSHI AEGPADLEDP FNPKAQLVLV GATFPEGVGQ LLNKVASPDA VTTITSSKLH CIMPHVKQTF LRLKGADK
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 82%.
WDR11 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DEAD (Asp-Glu-Ala-Asp) box polypeptide 28; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 28; Mitochondrial DEAD box protein 28; mitochondrial DEAD-box polypeptide 28; Probable ATP-dependent RNA helicase DDX28
基因别名: DDX28; MDDX28
UniProt ID: (Human) Q9NUL7
Entrez Gene ID: (Human) 55794