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产品信息
PA5-120933
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DDX3X (NP_0013473)
偶联物
形式
Liquid
浓度
2.01 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2914505
产品详细信息
Positive test controls include: C2C12, C6, Mouse brain, Rat liver. The target is usually found in the following locations: Cytoplasm, Mitochondrion outer membrane, Nucleus speckle.
Immunogen sequence: AGLDLNSSDN QSGGSTA
靶标信息
The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants.
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生物信息学
蛋白别名: ATP-dependent RNA helicase DDX3X; CAP-Rf; D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 3; D1Pas1-related sequence 2; DBX; DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 3; DEAD box protein 3, X-chromosomal; DEAD box RNA helicase DEAD3; DEAD box, X isoform; DEAD-box protein 3 (DEAD-box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1PAS1 related sequence 2); DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked; DEAD/H box-3; Embryonic RNA helicase; fibroblast growth factor inducible 14; Helicase-like protein 2; HLP2; mDEAD3
基因别名: CAP-Rf; D1Pas1-rs2; DBX; DDX14; DDX3; DDX3X; Dead3; Erh; Fin14; HLP2; MRX102
UniProt ID: (Human) O00571, (Mouse) Q62167
Entrez Gene ID: (Human) 1654, (Rat) 317335, (Mouse) 13205
DNA binding
RNA binding
GTPase activity
ATP-dependent DNA helicase activity
ATP-dependent RNA helicase activity
protein binding
ATP binding
transcription factor binding
poly(A) binding
eukaryotic initiation factor 4E binding
ATPase activity
nucleoside-triphosphatase activity
translation initiation factor binding
RNA stem-loop binding
ribosomal small subunit binding
CTPase activity
poly(A) RNA binding
mRNA 5'-UTR binding
cadherin binding involved in cell-cell adhesion
nucleotide binding
nucleic acid binding
helicase activity
hydrolase activity
transcription, DNA-templated
chromosome segregation
extrinsic apoptotic signaling pathway via death domain receptors
response to virus
RNA secondary structure unwinding
positive regulation of gene expression
Wnt signaling pathway
negative regulation of translation
positive regulation of cell growth
negative regulation of cell growth
negative regulation of protein complex assembly
DNA duplex unwinding
positive regulation of interferon-beta production
stress granule assembly
intracellular signal transduction
mature ribosome assembly
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of viral genome replication
innate immune response
positive regulation of translation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of translational initiation
cellular response to arsenic-containing substance
cellular response to osmotic stress
positive regulation of chemokine (C-C motif) ligand 5 production
intrinsic apoptotic signaling pathway
cell-cell adhesion
positive regulation of G1/S transition of mitotic cell cycle
protein localization to cytoplasmic stress granule
negative regulation of intrinsic apoptotic signaling pathway
immune system process
regulation of transcription, DNA-templated
translational initiation
regulation of translation
apoptotic process
regulation of gene expression
ribosome biogenesis
