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DERL2 Antibody (PA5-115111) in ICC/IF
Immunocytochemistry analysis of DERL2 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115111) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
产品信息
PA5-115111
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human DERL2(Accession Q9GZP9), corresponding to amino acid residues P193-G239.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899747
产品详细信息
Antibody detects endogenous levels of total DERL2.
靶标信息
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: carcinoma related; Degradation in endoplasmic reticulum protein 2; Der1-like domain family, member 2; Der1-like protein 2; derlin 2; Derlin-2; derlin-2-like; DERtrin-2; F-LAN-1; F-LANa
基因别名: CGI-101; DER2; DERL2; Derlin-2; DERtrin-2; F-LAN-1; F-LANa; FLANA; SBBI53
UniProt ID: (Human) Q9GZP9, (Mouse) Q8BNI4
Entrez Gene ID: (Human) 51009, (Mouse) 116891, (Rat) 100910823
suckling behavior
positive regulation of cell proliferation
positive regulation of cell growth
ER-associated ubiquitin-dependent protein catabolic process
endoplasmic reticulum unfolded protein response
retrograde protein transport, ER to cytosol
negative regulation of retrograde protein transport, ER to cytosol
endoplasmic reticulum mannose trimming
response to unfolded protein
