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DIABLO Antibody (PA5-96163) in IHC (P)
Immunohistochemistry analysis of DIABLO in paraffin-embedded mouse testis. Samples were incubated with DIABLO Polyclonal antibody (Product # PA5-96163) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
PA5-96163
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 56-239 of human Smac/Diablo (NP_0639401)
偶联物
形式
Liquid
浓度
1.93 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807965
产品详细信息
Immunogen sequence: AVPIAQKSEP HSLSSEALMR RAVSLVTDST STFLSQTTYA LIEAITEYTK AVYTLTSLYR QYTSLLGKMN SEEEDEVWQV IIGARAEMTS KHQEYLKLET TWMTAVGLSE MAAEAAYQTG ADQASITARN HIQLVKLQVE EVHQLSRKAE TKLAEAQIEE LRQKTQEEGE ERAESEQEAY LRED
Positive Samples: SW620, BT-474, Mouse spleen; Cellular Location: Mitochondrion
靶标信息
DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms. Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Diablo homolog, mitochondrial; Diablo IAP-binding mitochondrial protein; diablo, IAP-binding mitochondrial protein; diablo-like protein; DIABLO-S; direct IAP binding protein with low PI; Direct IAP-binding protein with low pI; FLJ10537; FLJ25049; hCG_1782202; Second mitochondria-derived activator of caspase; Second mitochondria-derived activator of caspases; SMAC; SMAC3
基因别名: 0610041G12Rik; 1700006L01Rik; AU040403; DFNA64; DIABLO; SMAC
UniProt ID: (Human) Q9NR28, (Mouse) Q9JIQ3
Entrez Gene ID: (Human) 56616, (Mouse) 66593, (Rat) 288753
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
intrinsic apoptotic signaling pathway in response to oxidative stress
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
positive regulation of apoptotic process
neuron apoptotic process
intrinsic apoptotic signaling pathway
extrinsic apoptotic signaling pathway via death domain receptors
