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产品信息
PA5-45040
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the C-terminal of human DNAJC2 (aa 417-466).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2605858
产品详细信息
Peptide sequence: EINEQIRKEK EEAEARMRQA SKNTEKSTGG GGNGSKNWSE DDLQLLIKAV
Sequence homology: Cow: 86%; Dog: 92%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 92%; Rabbit: 93%; Rat: 93%
靶标信息
EIF4EBP1 is one member of a family of translation repressor proteins. It directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DnaJ (Hsp40) homolog, subfamily C, member 2; DnaJ homolog subfamily C member 2; M-phase phosphoprotein 11; zuotin related factor 1; Zuotin-related factor 1
基因别名: DNAJC2; MPHOSPH11; MPP11; ZRF1; ZUO1
UniProt ID: (Human) Q99543
Entrez Gene ID: (Human) 27000
DNA replication
transcription, DNA-templated
covalent chromatin modification
negative regulation of cell growth
positive regulation of ATPase activity
positive regulation of transcription, DNA-templated
'de novo' cotranslational protein folding
regulation of cellular response to heat
negative regulation of DNA biosynthetic process
