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Antibody detects endogenous levels of total DNASE2B.
The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene.
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蛋白别名: deoxyribonuclease DLAD; Deoxyribonuclease II beta; Deoxyribonuclease-2-beta; DNA for uricase; DNase II beta; DNase II-like acid DNase; DNase2-like acid DNase; DNaseII-like acid DNase; Endonuclease DLAD; lysosomal DNase II
基因别名: DLAD; DNASE2B; UOX
UniProt ID: (Human) Q8WZ79, (Rat) Q9QZK9
Entrez Gene ID: (Human) 58511, (Rat) 59296
分子生物学功能:
endodeoxyribonuclease