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Recommended positive controls: A549.
Predicted reactivity: Human (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Deoxyribonuclease II beta; Deoxyribonuclease-2-beta; DNase II beta; DNase II-like acid DNase; DNase2-like acid DNase; Endonuclease DLAD; lysosomal DNase II
基因别名: DLAD; DNASE2B
UniProt ID: (Human) Q8WZ79
Entrez Gene ID: (Human) 58511
分子生物学功能:
endodeoxyribonuclease