Invitrogen

DNMT3B Polyclonal Antibody

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DNMT3B Antibody (PA5-32218) in WB

Western Blot using DNMT3B Polyclonal Antibody (Product # PA5-32218). Sample (30 µg of whole cell lysate). Lane A: Non-transfected 293T lysates. Lane B: DNMT3B transfected 293T lysates . 7.5% SDS PAGE. DNMT3B Polyclonal Antibody (Product # PA5-32218) diluted at 1:1,000.

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产品信息

PA5-32218

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein fragment corresponding to a region within amino acids 601 and 889 of Mouse DNMT3B

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2549691

产品详细信息

Recommended positive controls: Recombinant DNMT3B protein.

Predicted reactivity: Human (94%), Mouse (100%), Rat (99%), Pig (95%), Bovine (95%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DNA (cytosine-5)-methyltransferase 3B; DNA (cytosine-5-)-methyltransferase 3 beta; DNA methyltransferase HsaIIIB; DNA methyltransferase MmuIIIB; DNA MTase HsaIIIB; DNA MTase MmuIIIB; Dnmt3; Dnmt3b; m.MmuIIIB; MGC1090

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基因别名: DNMT3B; ICF; ICF1; M.HsaIIIB; MmuIIIB

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UniProt ID: (Human) Q9UBC3, (Mouse) O88509

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Entrez Gene ID: (Human) 1789, (Mouse) 13436

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