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产品信息
MA5-38512
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
7E5E9C1
抗原
Purified recombinant fragment of human DNMT3B (aa: 1-150) expressed in E. Coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2898425
产品详细信息
This antibody has been tested in indirect ELISA.
靶标信息
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA (cytosine-5)-methyltransferase 3B; DNA (cytosine-5-)-methyltransferase 3 beta; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; Dnmt3; Dnmt3b; m.MmuIIIB; MGC1090
基因别名: DNMT3B; ICF; ICF1; M.HsaIIIB
UniProt ID: (Human) Q9UBC3
Entrez Gene ID: (Human) 1789
chromatin binding
transcription corepressor activity
DNA (cytosine-5-)-methyltransferase activity
protein binding
DNA-methyltransferase activity
histone deacetylase binding
unmethylated CpG binding
metal ion binding
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
DNA methyltransferase
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
DNA methylation
response to toxic substance
response to ionizing radiation
DNA methylation on cytosine within a CG sequence
positive regulation of gene expression
response to activity
response to caffeine
response to estradiol
response to vitamin A
response to cocaine
response to drug
positive regulation of neuron differentiation
negative regulation of gene expression, epigenetic
S-adenosylhomocysteine metabolic process
S-adenosylmethioninamine metabolic process
positive regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
cellular response to hyperoxia
cellular response to dexamethasone stimulus
C-5 methylation of cytosine
