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DOCK11 Antibody (A301-639A) in IP
Detection of human DOCK11 by western blot of immunoprecipitates. Samples: Whole cell lysate (1.0 mg per IP reaction; 20% of IP loaded) from HeLa cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-DOCK11 antibody (Product # A301-639A; lot A301-639A-2) used for IP at 6 µg per reaction. DOCK11 was also immunoprecipitated by a previous lot of this antibody (lot A301-639A-1). For blotting immunoprecipitated DOCK11, Product # A301-638A was used at 1 µg/mL. Detection: Chemiluminescence with an exposure time of 30 se... View More
产品信息
A301-639A
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 400 and 450 of human dedicator of cytokinesis 11.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
tris citrate/phosphate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
靶标信息
Small GTPases of the Rho family, Rho, Rac, and Cdc42, are critical regulators of the actin cytoskeleton and many other cellular processes. Rho GTPases are activated by Dbl-homology (DH)-domain-containing guanine nucleotide exchange factors (GEFs). DOCK 11 (dedicator of cytokinesis 11), also known as ACG or ZIZ2 (zizimin2), is a 2073 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins that is mainly expressed in peripheral blood leukocytes. DOCK 11 functions as a GEF that binds and activates Cdc42 by exchanging bound GDP for free GTP. Cdc42 mediates cell polarity, gene expression, cell cycle progression and cell-cell contacts. Similar to other DOCK family members, DOCK 11 contains a PH domain and two internal DOCK homology regions designated DHR1 and DHR2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ACG; Activated Cdc42-associated guanine nucleotide exchange factor; Activated Cdc42-associated guanine nucleotide exchange factor, ACG; bB128O4.1.1 (novel protein); Dedicator of cytokinesis protein 11; DOCK-11; Zizimin 2; Zizimin-2; zizimin2
基因别名: ACG; bB128O4.1; DOCK11; ZIZ2
UniProt ID: (Human) Q5JSL3
Entrez Gene ID: (Human) 139818
