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DOCK11 Antibody (PA5-103778) in IHC (P)
Immunohistochemistry analysis of DOCK11 in rat heart tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with DOCK11 polyclonal antibody (Product # PA5-103778) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-103778
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human DOCK11(Accession Q5JSL3), corresponding to amino acid residues R1325-S1375.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2853111
产品详细信息
Antibody detects endogenous levels of total DOCK11.
靶标信息
Small GTPases of the Rho family, Rho, Rac, and Cdc42, are critical regulators of the actin cytoskeleton and many other cellular processes. Rho GTPases are activated by Dbl-homology (DH)-domain-containing guanine nucleotide exchange factors (GEFs). DOCK 11 (dedicator of cytokinesis 11), also known as ACG or ZIZ2 (zizimin2), is a 2073 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins that is mainly expressed in peripheral blood leukocytes. DOCK 11 functions as a GEF that binds and activates Cdc42 by exchanging bound GDP for free GTP. Cdc42 mediates cell polarity, gene expression, cell cycle progression and cell-cell contacts. Similar to other DOCK family members, DOCK 11 contains a PH domain and two internal DOCK homology regions designated DHR1 and DHR2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ACG; Activated Cdc42-associated guanine nucleotide exchange factor; Activated Cdc42-associated guanine nucleotide exchange factor, ACG; bB128O4.1.1 (novel protein); Dedicator of cytokinesis protein 11; DOCK-11; spleen specific 238 kDa protein with PH domain; Zizimin 2; Zizimin-2; zizimin2
基因别名: 5033414A21Rik; 8030476J24; ACG; bB128O4.1; DOCK11; sph238; ZIZ2; Zizimin2
UniProt ID: (Human) Q5JSL3, (Mouse) A2AF47
Entrez Gene ID: (Human) 139818, (Rat) 313438, (Mouse) 75974
