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This gene encodes two principal proteins of the dentin extracellular matrix of the tooth. The preproprotein is secreted by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is thought to be involved in the biomineralization process of dentin. Mutations in this gene have been associated with dentinogenesis imperfecta-1; in some individuals, dentinogenesis imperfecta occurs in combination with an autosomal dominant form of deafness. Allelic differences due to repeat polymorphisms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: dentin phosphophoryn; dentin phosphoprotein; dentin phosphoryn; Dentin sialophosphoprotein; dentin sialoprotein; DTDP2
基因别名: DFNA39; DGI1; DMP3; DPP; DSP; DSPP
UniProt ID: (Human) Q9NZW4
Entrez Gene ID: (Human) 1834