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DUSP14 Antibody (H00011072-D01P) in WB
Western Blot analysis of DUSP14 expression in transfected 293T cell line (H00011072-T02) by DUSP14 MaxPab polyclonal antibody.
Lane 1: DUSP14 transfected lysate(22.30 KDa).
Lane 2: Non-transfected lysate.
Lane 1: DUSP14 transfected lysate(22.30 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00011072-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
DUSP14 (NP_008957.1, 1 a.a. approximately 198 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MSSRGHSTLP RTLMAPRMIS EGDIGGIAQI TSSLFLGRGS VASNRHLLQA RGITCIVNAT IEIPNFNWPQ FEYVKVPLAD MPHAPIGLYF DTVADKIHSV SRKHGATLVH CAAGVSRSAT LCIAYLMKFH NVCLLEAYNW VKARRPVIRP NVGFWRQLID YERQLFGKST VKMVQTPYGI VPDVYEKESR HLMPYWGI
靶标信息
In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80; MIM 112203) and B7-2 (CD86; MIM 601020) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 (IL2; MIM 147680) and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK (e.g., MAP2K4; MIM 601335) and JNK (see MIM 601158), and the subsequent creation of AP1 transcription factor (see MIM 165160). DUSP14 is a negative regulator of CD28 signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dual specificity protein phosphatase 14; MAP kinase phosphatase 6; Mitogen-activated protein kinase phosphatase 6; MKP-1 like protein tyrosine phosphatase; MKP-1-like protein tyrosine phosphatase; MKP-6; MKP-L
基因别名: DUSP14; MKP-L; MKP6
UniProt ID: (Human) O95147
Entrez Gene ID: (Human) 11072
