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产品信息
PA5-33487
产品规格
种属反应
Bovine,
Horse,
Human,
Non-human primate,
Rabbit
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 17 amino acid peptide from near N-terminus of human DUSP22.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2550867
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Bovine, Horse, Rabbit (100%) Mouse, Rat (94%) Elephant, Chicken (88%) Xenopus (82%).
靶标信息
Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. DUSP22 dephosphorylates ERK2 MAP kinase and JNK. DUSP22 displays highest in thymus, but it is also detectable in monocytes and lymphocytes.
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生物信息学
蛋白别名: DKFZp586F2224; Dual specificity protein phosphatase 22; homolog of mouse dual specificity phosphatase LMW-DSP2; JKAP; JNK pathway associated phosphatase; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; JSP 1; JSP-1; LMW-DSP2; Low molecular weight dual specificity phosphatase 2; MAP kinase phosphatase x; mi; Mitogen-activated protein kinase phosphatase x; PYST2
基因别名: DUSP22; JKAP; JSP-1; JSP1; LMW-DSP2; LMWDSP2; MKP-x; MKPX; VHX
UniProt ID: (Human) Q9NRW4
Entrez Gene ID: (Human) 56940, (Horse) 100054792, (Rabbit) 100353877
negative regulation of transcription from RNA polymerase II promoter
inactivation of MAPK activity
negative regulation of T cell mediated immunity
protein dephosphorylation
apoptotic process
transforming growth factor beta receptor signaling pathway
multicellular organism development
cell proliferation
peptidyl-tyrosine dephosphorylation
regulation of cell proliferation
positive regulation of JNK cascade
negative regulation of T cell receptor signaling pathway
negative regulation of T cell activation
