Invitrogen

Decorin Polyclonal Antibody

Decorin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Decorin Antibody (PA5-27370) in IHC (P)

Immunohistochemical analysis of paraffin-embedded TOV112D xenograft, using Decorin (Product # PA5-27370) antibody at 1:100 dilution. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.

Decorin Antibody in Immunocytochemistry (ICC/IF)

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产品信息

PA5-27370

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

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免疫组化（石蜡） (IHC (P))

1:100-1:1,000

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免疫细胞化学 (ICC/IF)

1:100-1:1,000

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免疫沉淀 (IP)

Assay-dependent

in situ PLA (PLA)

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其他PubMed (Misc)

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产品规格

种属反应

Human

已发表种属

Horse, Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 1 and 192 of Human Decorin

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 40% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2544846

产品详细信息

Recommended positive controls: A549, H1299.

Predicted reactivity: Mouse (82%), Rat (80%), Dog (91%), Pig (88%), Rabbit (90%), Sheep (86%), Chimpanzee (100%), Bovine (87%), Guinea pig (87%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Decorin is a member of the small, leucine-rich proteoglycan (SLRP) family along with biglycan. Found in the interterritorial region of cartilage, decorin interacts with collagen and other matrix proteins to regulate the cartilaginous matrix. It has been shown to interact with fibronectin, thrombospondin, C1q, epidermal growth factor receptor (EGFR), and TGF-b. It is believed that decorin also plays a role in the cell cycle of chondrocytes. The decorin neoepitope fragment has a sequence of PKTLQE, and is generated by MMP-3 or ADAMTS-4 cleavage at Glu154-Leu155 of decorin core protein.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Alves AL,Carvalho AC,Machado I,Diogo GS,Fernandes EM,Castro VIB,Pires RA,Vázquez JA,Pérez-Martín RI,Alaminos M,Reis RL,Silva TH

Published figure using Decorin polyclonal antibody (Product # PA5-27370) in Immunocytochemistry

Wed Jan 04 00:00:00 EST 2023

Characterization of the Proteins Secreted by Equine Muscle-Derived Mesenchymal Stem Cells Exposed to Cartilage Explants in Osteoarthritis Model.

Stem cell reviews and reports

Dechêne L,Colin M,Demazy C,Fransolet M,Niesten A,Arnould T,Serteyn D,Dieu M,Renard P

PA5-27370 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to suggest that muscle-derived MSCs could reduce the catabolic effect of TNFα and IL-1β on cartilage explant by decreasing the secretion and activity of matrix metalloproteinase 3 and increasing the decorin secretion.

Wed Feb 01 00:00:00 EST 2023

Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein.

Cells

Bang-Christensen SR,Pedersen RS,Pereira MA,Clausen TM,Løppke C,Sand NT,Ahrens TD,Jørgensen AM,Lim YC,Goksøyr L,Choudhary S,Gustavsson T,Dagil R,Daugaard M,Sander AF,Torp MH,Søgaard M,Theander TG,Østrup O,Lassen U,Hamerlik P,Salanti A,Agerbæk MØ

PA5-27370 was used in Proximity Ligation Assay (PLA) to present a method for enriching and staining CTCs from glioma patients.

Wed Aug 28 00:00:00 EDT 2019

Leptospira interrogans causes quantitative and morphological disturbances in adherens junctions and other biological groups of proteins in human endothelial cells.

PLoS neglected tropical diseases

Sato H,Coburn J

Published figure using Decorin polyclonal antibody (Product # PA5-27370) in Immunofluorescence

Sat Jul 01 00:00:00 EDT 2017

Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1.

PLoS pathogens

Ayres Pereira M,Mandel Clausen T,Pehrson C,Mao Y,Resende M,Daugaard M,Riis Kristensen A,Spliid C,Mathiesen L,E Knudsen L,Damm P,G Theander T,R Hansson S,A Nielsen M,Salanti A

Published figure using Decorin polyclonal antibody (Product # PA5-27370) in Immunofluorescence

Mon Aug 01 00:00:00 EDT 2016

Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1.

PLoS pathogens

Ayres Pereira M,Mandel Clausen T,Pehrson C,Mao Y,Resende M,Daugaard M,Riis Kristensen A,Spliid C,Mathiesen L,E Knudsen L,Damm P,G Theander T,R Hansson S,A Nielsen M,Salanti A

Published figure using Decorin polyclonal antibody (Product # PA5-27370) in Immunofluorescence

Mon Aug 01 00:00:00 EDT 2016

生物信息学

蛋白别名: Bone proteoglycan II; Decorin; dermatan sulphate proteoglycans II; Dermatan sulphate proteoglycans II (DSPG2); PG-S2; PG40; proteoglycan core protein; Small leucine rich protein 1B; small leucine-rich protein 1B

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基因别名: CSCD; DCN; DSPG2; PG40; PGII; PGS2; SLRR1B

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UniProt ID: (Human) P07585

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Entrez Gene ID: (Human) 1634

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功能

protein kinase inhibitor activity protein binding collagen binding glycosaminoglycan binding poly(A) RNA binding protein N-terminus binding extracellular matrix binding

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