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产品信息
1634-MSM4-P0
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Dog,
Chicken,
Deer,
Horse,
Human,
Mouse,
Pig,
Rabbit
宿主/亚型
Mouse
/ IgG1, lambda
分类
Monoclonal
类型
Antibody
克隆号
DCN/6289
抗原
Recombinant full-length DCN protein
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C, do not freeze
运输条件
Wet ice
靶标信息
Decorin is a member of the small, leucine-rich proteoglycan (SLRP) family along with biglycan. Found in the interterritorial region of cartilage, decorin interacts with collagen and other matrix proteins to regulate the cartilaginous matrix. It has been shown to interact with fibronectin, thrombospondin, C1q, epidermal growth factor receptor (EGFR), and TGF-b. It is believed that decorin also plays a role in the cell cycle of chondrocytes. The decorin neoepitope fragment has a sequence of PKTLQE, and is generated by MMP-3 or ADAMTS-4 cleavage at Glu154-Leu155 of decorin core protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Bone proteoglycan II; Decorin; Dermatan sulfate proteoglycan II; dermatan sulphate proteoglycans II; Dermatan sulphate proteoglycans II (DSPG2); DS-PGII; PG-S2; PG40; proteoglycan; proteoglycan core protein; proteoglycan core protein; binds type I collagen fibers and TGF-beta; decoron; Small leucine rich protein 1B; small leucine-rich protein 1B; unnamed protein product
基因别名: CSCD; DC; DCN; DCN1C; DSPG2; mDcn; PG40; PGII; PGS2; SLRR1B
UniProt ID: (Rabbit) Q28888, (Human) P07585, (Bovine) P21793, (Pig) Q9XSD9, (Dog) Q29393, (Horse) O46542, (Chicken) P28675, (Mouse) P28654
Entrez Gene ID: (Rabbit) 100009171, (Human) 1634, (Bovine) 280760, (Pig) 396957, (Dog) 403904, (Horse) 100034120, (Chicken) 417892, (Mouse) 13179
protein kinase inhibitor activity
protein binding
collagen binding
glycosaminoglycan binding
poly(A) RNA binding
protein N-terminus binding
extracellular matrix binding
extracellular matrix structural constituent conferring compression resistance
protein homodimerization activity
collagen fibril binding
positive regulation of autophagy
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
kidney development
placenta development
negative regulation of protein kinase activity
skeletal muscle tissue development
aging
response to mechanical stimulus
organ morphogenesis
negative regulation of endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of macroautophagy
negative regulation of angiogenesis
cytokine-mediated signaling pathway
extracellular matrix disassembly
extracellular matrix organization
glycosaminoglycan metabolic process
chondroitin sulfate biosynthetic process
chondroitin sulfate catabolic process
dermatan sulfate biosynthetic process
response to lipopolysaccharide
wound healing
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JAK-STAT cascade
positive regulation of mitochondrial depolarization
positive regulation of mitochondrial fission
negative regulation of vascular endothelial growth factor signaling pathway
negative regulation of collagen fibril organization
