Invitrogen

Dectin 1 Polyclonal Antibody

高级验证

This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.

2个已发表图片

2 篇参考文献

查看其他27个Dectin 1 (Clec7a)抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

Dectin 1 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 6

Dectin 1 Antibody (PA5-34382) in ICC/IF

Immunofluorescence of CLEC7A in Jurkat cells with Dectin 1 Polyclonal Antibody (Product # PA5-34382) at 20 µg/mL.

Dectin 1 Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-34382

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-2 µg/mL

查看2篇已发表文章 2篇已发表文章

免疫组化 (IHC)

5 µg/mL

免疫细胞化学 (ICC/IF)

20 µg/mL

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A 17 amino acid synthetic peptide near the center of human CLEC7A

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2551734

产品详细信息

A suggested positive control is rat spleen tissue lysate.

PA5-34382 can be used with blocking peptide PEP-1425.

靶标信息

CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Human Dectin-1 deficiency impairs macrophage-mediated defense against phaeohyphomycosis.

The Journal of clinical investigation

Drummond RA,Desai JV,Hsu AP,Oikonomou V,Vinh DC,Acklin JA,Abers MS,Walkiewicz MA,Anzick SL,Swamydas M,Vautier S,Natarajan M,Oler AJ,Yamanaka D,Mayer-Barber KD,Iwakura Y,Bianchi D,Driscoll B,Hauck K,Kline A,Viall NS,Zerbe CS,Ferré EM,Schmitt MM,DiMaggio T,Pittaluga S,Butman JA,Zelazny AM,Shea YR,Arias CA,Ashbaugh C,Mahmood M,Temesgen Z,Theofiles AG,Nigo M,Moudgal V,Bloch KC,Kelly SG,Whitworth MS,Rao G,Whitener CJ,Mafi N,Gea-Banacloche J,Kenyon LC,Miller WR,Boggian K,Gilbert A,Sincock M,Freeman AF,Bennett JE,Hasbun R,Mikelis CM,Kwon-Chung KJ,Belkaid Y,Brown GD,Lim JK,Kuhns DB,Holland SM,Lionakis MS

Published figure using Dectin 1 polyclonal antibody (Product # PA5-34382) in Western Blot

Tue Nov 15 00:00:00 EST 2022

Immunoregulatory Activity of the Natural Product Laminarin Varies Widely as a Result of Its Physical Properties.

Journal of immunology (Baltimore, Md. : 1950)

Smith AJ,Graves B,Child R,Rice PJ,Ma Z,Lowman DW,Ensley HE,Ryter KT,Evans JT,Williams DL

PA5-34382 was used in Western Blotting to show that laminarin can be either a Dectin-1 antagonist or agonist depending on the physiochemical properties, purity and structure of the laminarin preparation employed.

Mon Jan 15 00:00:00 EST 2018

生物信息学

蛋白别名: Beta-glucan receptor; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; C-type lectin superfamily member 12; CD369; DC-associated C-type lectin 1; dectin-1; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1

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基因别名: beta-GR; BGR; CANDF4; CD369; CLEC7A; Clec7b; CLECSF12; DECTIN1; RGD1565140; SCARE2; UNQ539/PRO1082

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UniProt ID: (Human) Q9BXN2

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Entrez Gene ID: (Human) 64581, (Mouse) 56644, (Rat) 502902

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功能

protein binding signaling pattern recognition receptor activity carbohydrate binding MHC protein binding metal ion binding opsonin binding (1->3)-beta-D-glucan binding (1->3)-beta-D-glucan receptor activity polysaccharide binding

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