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Dectin 1 Antibody (MA5-58112) in IHC (P)
Immunohistochemistry analysis of Dectin 1 with paraffin-embedded Mouse spleen tissue. The tissue was incubated with Dectin 1 Recombinant Monoclonal Antibody (Product # MA5-58112) using a 1:200 dilution (40x lens). Followed by Cy3-conjugated Goat anti-Rabbit IgG (H+L) Secondary Antibody (Red) using a 1:500 dilution. DAPI was used for nuclear staining (Blue). High pressure antigen retrieval performed with 0.0... View More
产品信息
MA5-58112
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
7L10N4
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 66-247 of human Dectin-1 (NP_922938.1).
偶联物
Unconjugated
形式
Liquid
浓度
1.04 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: TMAIWRSNSG SNTLENGYFL SRNKENHSQP TQSSLEDSVT PTKAVKTTGV LSSPCPPNWI IYEKSCYLFS MSLNSWDGSK RQCWQLGSNL LKIDSSNELG FIVKQVSSQP DNSFWIGLSR PQTEVPWLWE DGSTFSSNLF QIRTTATQEN PSPNCVWIHV SVIYDQLCSV PSYSICEKKF SM
靶标信息
CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: beta-glucan receptor; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin superfamily member 12; DC-associated C-type lectin 1; dectin-1; dendritic cell-associated C-type lectin 1
基因别名: beta-GR; BGR; Clec7b; Clecsf12; RGD1565140
Entrez Gene ID: (Mouse) 56644, (Rat) 502902
