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产品信息
A303-513A
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 625 and 675 of human Dynamin 2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
phosphate/tris citrate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat and Bovine
靶标信息
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dynamin 2; Dynamin II; Dynamin-2
基因别名: CMT2M; CMTDI1; CMTDIB; DI-CMTB; DNM2; DYN2; DYNII; LCCS5
UniProt ID: (Human) P50570
Entrez Gene ID: (Human) 1785
GTPase activity
protein binding
GTP binding
microtubule binding
SH3 domain binding
enzyme binding
protein kinase binding
D2 dopamine receptor binding
protein complex binding
phosphatidylinositol 3-kinase regulatory subunit binding
WW domain binding
nitric-oxide synthase binding
membrane traffic protein
G2/M transition of mitotic cell cycle
G-protein coupled receptor internalization
ventricular septum development
regulation of transcription, DNA-templated
Golgi to plasma membrane transport
endocytosis
receptor-mediated endocytosis
phagocytosis
signal transduction
spermatogenesis
response to light stimulus
positive regulation of lamellipodium assembly
antigen processing and presentation of exogenous peptide antigen via MHC class II
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of axon extension
receptor internalization
transferrin transport
regulation of Rac protein signal transduction
aorta development
response to cocaine
positive regulation of apoptotic process
macropinocytosis
positive regulation of nitric oxide biosynthetic process
positive regulation of transcription, DNA-templated
synaptic vesicle transport
neuron projection morphogenesis
positive regulation of phagocytosis
regulation of nitric-oxide synthase activity
cilium morphogenesis
coronary vasculature development
cellular response to carbon monoxide
cellular response to X-ray
cellular response to nitric oxide
positive regulation of substrate adhesion-dependent cell spreading
cellular response to dopamine
regulation of Golgi organization
positive regulation of sodium:potassium-exchanging ATPase activity
negative regulation of membrane tubulation
