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产品信息
MA5-35927
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
GT885
抗原
Recombinant protein encompassing a sequence within the center region of Human EED. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1.54 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2866544
靶标信息
The EED protein (WAIT-1 or WD protein associated with integrin cytoplasmic tails-1), also called embryonic ectoderm development, is a member of the superfamily of WD-40 repeat proteins and widely conserved polycomb group (PcG) family of proteins. The polycomb group (PcG) is a large and evolutionarily conserved set of genes whose products act in multimeric complexes to modify histones, which are then thought to cause stable and heritable states of transcriptional repression. EED shuttles between the nucleus and the plasma membrane and can interact with the cytoplasmic tail of integrin Beta-7 subunit. EED exerted an antiviral activity at the late stage of HIV-1 replication.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Embryonic ectoderm development protein; hEED; lethal, Chr 7, Rinchik 5; Polycomb protein EED; WAIT-1; WD protein associating with integrin cytoplasmic tails 1
基因别名: EED; ENSMUSG00000039373; HEED; l(7)5Rn; l7Rn5; lusk; WAIT1
UniProt ID: (Human) O75530, (Mouse) Q921E6
Entrez Gene ID: (Human) 8726, (Mouse) 13626, (Rat) 293104
negative regulation of transcription from RNA polymerase II promoter
regulation of gene expression by genetic imprinting
transcription, DNA-templated
histone methylation
spinal cord development
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of histone H3-K27 methylation
regulation of transcription, DNA-templated
chromatin modification
