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ELOVL1 Antibody (PA5-99293) in IHC (P)
Immunohistochemistry analysis of ELOVL1 in mouse colorectal tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with ELOVL1 polyclonal antibody (Product # PA5-99293) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-99293
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ELOVL1(Accession Q9BW60), corresponding to amino acid residues V108-I158.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2818226
产品详细信息
Antibody detects endogenous levels of total ELOVL1.
靶标信息
Elongation of very long chain fatty acid-like (ELOVL) proteins 1-6 are members of the ELO family of proteins, which play an important role in tissue-specific biosynthesis of very long chain fatty acids and sphingolipids. The ELOVL proteins act as catalysts in fatty acid elongation reduction and localize to the endoplasmic reticulum (ER). Elongation of very long chain fatty acids protein 1 (ELOVL1), also referred to as Ssc1, is the human homolog of the yeast ELO3 protein. It is expressed in a variety of tissues and at especially high levels in stomach, skin, intestine, kidney and lung. ELOVL1 participates in the elongation of very long chain saturated and monounsaturated fatty acids of up to 26 carbons and may be required for the development of a barrier in epithelial cells and skin. ELOVL1 is also important for the formation of Myelin in the central nervous system. Impaired ELOVL1 activity may be associated with disorders of sphingolipid metabolism.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3-keto acyl-CoA synthase ELOVL1; CGI88; elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1; Elongation of very long chain fatty acids protein 1; ELOVL FA elongase 1; ELOVL fatty acid elongase 1; sequence similarity to Cig30 1; Very long chain 3-ketoacyl-CoA synthase 1; Very long chain 3-oxoacyl-CoA synthase 1; Very long chain fatty acid elongase 1; very-long-chain 3-oxoacyl-CoA synthase 1
基因别名: AA407424; BB151133; CGI-88; ELOVL1; SSC1
UniProt ID: (Human) Q9BW60, (Mouse) Q9JLJ5
Entrez Gene ID: (Human) 64834, (Rat) 679532, (Mouse) 54325
unsaturated fatty acid biosynthetic process
fatty acid elongation, saturated fatty acid
sphingolipid biosynthetic process
fatty acid elongation, monounsaturated fatty acid
fatty acid elongation, polyunsaturated fatty acid
long-chain fatty-acyl-CoA biosynthetic process
alpha-linolenic acid metabolic process
very long-chain fatty acid biosynthetic process
linoleic acid metabolic process
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
