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ENPP1 Antibody (PA5-119090) in IHC (P)
Immunohistochemistry analysis of ENPP1 in paraffin-embedded Rat Intestine tissue. Samples were incubated with polyclonal antibody (Product # PA5-119090) at a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.
产品信息
PA5-119090
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein Ectonucleotide Pyrophosphatase/Phosphodiesterase 1. The antigen corresponds to amino acid range 568-793 of the target protein.
偶联物
形式
Liquid
浓度
0.64 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2903590
靶标信息
This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alkaline phosphodiesterase I; E-NPP 1; Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; HGNC:3356; NPPase; Nucleotide diphosphatase; Nucleotide pyrophosphatase; OTTHUMP00000043194; Phosphodiesterase I/nucleotide pyrophosphatase 1; Plasma-cell membrane glycoprotein PC-1
基因别名: Enpp1; Npps; Pc1; Pdnp1
UniProt ID: (Rat) Q924C3
Entrez Gene ID: (Rat) 85496
molecular_function
nucleic acid binding
phosphodiesterase I activity
nucleotide diphosphatase activity
scavenger receptor activity
insulin receptor binding
calcium ion binding
ATP binding
zinc ion binding
polysaccharide binding
NADH pyrophosphatase activity
protein homodimerization activity
metal ion binding
nucleoside-triphosphate diphosphatase activity
generation of precursor metabolites and energy
phosphate-containing compound metabolic process
receptor-mediated endocytosis
immune response
biological_process
nucleoside triphosphate catabolic process
negative regulation of ossification
negative regulation of cell growth
inorganic diphosphate transport
cellular phosphate ion homeostasis
sequestering of triglyceride
biomineral tissue development
negative regulation of protein autophosphorylation
cellular response to insulin stimulus
negative regulation of fat cell differentiation
negative regulation of glycogen biosynthetic process
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
bone remodeling
3'-phosphoadenosine 5'-phosphosulfate metabolic process
nucleic acid phosphodiester bond hydrolysis
