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ERCC3 Antibody (PA5-109691) in WB
Western blot analysis of ERCC3 in extracts of various cell lines. Samples were incubated with ERCC3 Polyclonal antibody (Product # PA5-109691) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
产品信息
PA5-109691
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 512-782 of human ERCC3 (NP_000113.1).
偶联物
形式
Liquid
浓度
0.39 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855102
产品详细信息
Immunogen sequence: CPMSPEFYRE YVAIKTKKRI LLYTMNPNKF RACQFLIKFH ERRNDKIIVF ADNVFALKEY AIRLNKPYIY GPTSQGERMQ ILQNFKHNPK INTIFISKVG DTSFDLPEAN VLIQISSHGG SRRQEAQRLG RVLRAKKGMV AEEYNAFFYS LVSQDTQEMA YSTKRQRFLV DQGYSFKVIT KLAGMEEEDL AFSTKEEQQQ LLQKVLAATD LDAEEEVVAG EFGSRSSQAS RRFGTMSSMS GADDTVYMEY HSSRSKAPSK HVHPLFKRFR K
靶标信息
The human XPB DNA helicase is a subunit of the DNA repair/basal transcription factor TFIIH, and is involved in early steps of the nucleotide excision repair (NER) pathway. Two distinct clinical phenotypes, xeroderma pigmentosum associated with Cockayne's syndrome (XP/CS) and trichothiodystrophy (TTD), can be due to mutations in the XPB gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Basic transcription factor 2 89 kDa subunit; BTF2 p89; BTF2-p89; DNA 3'-5' helicase/translocase XPB; DNA excision repair protein ERCC-3; DNA repair helicase; DNA repair protein complementing XP-B cells; excision repair 3; excision repair cross-complementation group 3; excision repair cross-complementing rodent repair deficiency, complementation group 3; General transcription and DNA repair factor IIH helicase/translocase subunit XPB; TFIIH 89 kDa subunit; TFIIH basal transcription factor complex 89 kDa subunit; TFIIH basal transcription factor complex helicase XPB subunit; TFIIH p89; TFIIH subunit XPB; Xeroderma pigmentosum group B-complementing protein; xeroderma pigmentosum, complementation group B
基因别名: BTF2; BTF2 p89; Ercc-3; ERCC3; GTF2H; RAD25; TFIIH; TTD2; XPB; XPBC
UniProt ID: (Human) P19447, (Mouse) P49135, (Rat) Q4G005
Entrez Gene ID: (Human) 2071, (Mouse) 13872, (Rat) 291703
DNA binding
damaged DNA binding
ATP-dependent DNA helicase activity
helicase activity
protein kinase activity
protein binding
ATP binding
GTP binding
protein C-terminus binding
DNA-dependent ATPase activity
transcription factor binding
RNA polymerase II carboxy-terminal domain kinase activity
ATPase activity
dATP binding
peptide binding
3'-5' DNA helicase activity
protein N-terminus binding
nucleotide binding
hydrolase activity
DNA metabolism protein
DNA helicase
nucleic acid metabolism protein
nucleotide-excision repair, DNA duplex unwinding
response to hypoxia
DNA topological change
DNA repair
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
7-methylguanosine mRNA capping
protein phosphorylation
apoptotic process
response to oxidative stress
protein localization
response to UV
UV protection
viral process
nucleotide-excision repair, DNA incision
hair cell differentiation
positive regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
global genome nucleotide-excision repair
regulation of mitotic cell cycle phase transition
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
