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NeoBiotechnologies
Endoglin/CD105 (Angiogenesis Marker) Monoclonal Antibody (ENG/1621)
产品信息
2022-MSM6-P0
应用
建议稀释比
已发表文章
产品规格
种属反应
Horse,
Human,
Non-human primate,
Pig,
Rat
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
ENG/1621
抗原
Recombinant extracellular fragment of human Endoglin protein exact sequence is proprietary)
偶联物
Unconjugated
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD105; CD105 antigen; Endoglin; endoglin (Osler-Rendu-Weber syndrome 1); ORW
基因别名: CD105; END; ENG; HHT1; ORW1
UniProt ID: (Human) P17813, (Pig) P37176
Entrez Gene ID: (Human) 2022, (Pig) 397096, (Horse) 100070421, (Rat) 497010
transmembrane signaling receptor activity
transforming growth factor beta receptor, cytoplasmic mediator activity
type II transforming growth factor beta receptor binding
protein binding
galactose binding
glycosaminoglycan binding
type I transforming growth factor beta receptor binding
BMP binding
protein homodimerization activity
activin binding
transforming growth factor beta binding
transforming growth factor beta-activated receptor activity
transmembrane signal receptor
chronological cell aging
patterning of blood vessels
vasculogenesis
positive regulation of protein phosphorylation
heart looping
sprouting angiogenesis
endocardial cushion morphogenesis
cardiac ventricle morphogenesis
cardiac atrium morphogenesis
ventricular trabecula myocardium morphogenesis
cell migration involved in endocardial cushion formation
regulation of transcription, DNA-templated
cell adhesion
negative regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
regulation of transforming growth factor beta receptor signaling pathway
central nervous system vasculogenesis
negative regulation of cell migration
BMP signaling pathway
positive regulation of BMP signaling pathway
negative regulation of protein autophosphorylation
dorsal aorta morphogenesis
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
smooth muscle tissue development
artery morphogenesis
venous blood vessel morphogenesis
endocardial cushion to mesenchymal transition
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
transforming growth factor beta receptor signaling pathway
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
response to hypoxia
negative regulation of endothelial cell proliferation
positive regulation of systemic arterial blood pressure
transmembrane receptor protein serine/threonine kinase signaling pathway
heart development
positive regulation of gene expression
cell migration
extracellular matrix disassembly
response to corticosteroid
positive regulation of collagen biosynthetic process
intracellular signal transduction
response to statin
wound healing
cell motility
negative regulation of nitric-oxide synthase activity
cell chemotaxis
bone development
negative regulation of pathway-restricted SMAD protein phosphorylation
extracellular matrix constituent secretion
detection of hypoxia
cellular response to mechanical stimulus
response to transforming growth factor beta
