Invitrogen

Endothelin 3 Polyclonal Antibody

Endothelin 3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Endothelin 3 Antibody (PA5-106860) in IHC (P)

Immunohistochemistry analysis of Endothelin 3 in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Endothelin 3 polyclonal antibody (Product # PA5-106860) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.

Endothelin 3 Antibody in Western Blot (WB)

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产品信息

PA5-106860

应用

建议稀释比

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免疫印迹 (WB)

1:500-1:2,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human EDN3(Accession P14138), corresponding to amino acid residues A186-G236.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2854524

产品详细信息

Antibody detects endogenous levels of total EDN3.

靶标信息

The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.

仅用于科研。不用于诊断过程。未经明确授权不得转售。